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- W2496069233 abstract "In our search for novel oligonucleotide analogues for use in therapy and DNA-based diagnostics we explored the concept of conformational preorganization as a means to improve duplex stability with complementary DNA and RNA. This research effort has led to a number of novel DNA analogues and has contributed to a deeper understanding of the interrelation between the structure of nucleosides and the properties of corresponding oligonucleotides. Some of these analogues show interesting biological properties. This article is a short review summarizing the properties of bicyclo-DNA and tricyclo-DNA, developed in our laboratory." @default.
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- W2496069233 date "2001-01-01" @default.
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- W2496069233 title "Conformationally restricted oligonucleotide analogues 'made in Bern': A mini review" @default.
- W2496069233 doi "https://doi.org/10.7892/boris.68588" @default.
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