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• W2496081115 abstract "This chapter discusses laboratory assessment for clinical diagnosis of hepatobiliary disease. Standard, routinely available, automated laboratory investigations for liver disease usually verify or exclude the presence of significant hepatobiliary disease. These investigations should include at least serum total bilirubin, an aminotransferase, gamma-glutamyl transpeptidase, alkaline phosphatase, total protein, and albumin. The results are of value in monitoring the progress of disease and in the assessment of possible hepatotoxic effects of new drugs. They are particularly important in identifying hepatic disease in the patient with no jaundice or other clinical features of liver disease. Abnormal results might lead to consideration of Reye's syndrome in acute unexplained coma. In such circumstances blood ammonia can be invaluable in directing attention to disorders such as urea cycle defects. The results of these investigations are frequently influenced by many non-hepatic factors. Serum albumin is formed by the liver. Hypoalbuminemia is found in advanced chronic liver diseases. This may be because of decreased synthesis or increased degradation but may also be because of an increased plasma volume. It is a useful but imprecise index of severity of liver damage. It is of little value in predicting the patient's prognosis or response to surgery such as portosystemic shunting. Temporary low levels are found in extrahepatic portal hypertension following alimentary bleeding." @default.
• W2496081115 created "2016-08-23" @default.
• W2496081115 creator A5086081024 @default.
• W2496081115 date "1979-01-01" @default.
• W2496081115 modified "2023-09-23" @default.
• W2496081115 title "Laboratory Assessment of Hepatobiliary Disease" @default.
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• W2496081115 doi "https://doi.org/10.1016/b978-0-407-00163-3.50027-5" @default.
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