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- W2496092771 abstract "Understanding the biological consequences of cellular heterogeneity is an unmet challenge. For example, heterogeneity of mitogen-activated protein kinase phosphorylation (pMAPK) in response to epidermal growth factor receptor (EGFR) activation is poorly understood in genetically identical cells. We used super-resolution microscopy to define EGFR clusters by receptor numbers (N) and average intra-cluster distances (d). From this data, we predicted the extent of pMAPK with 85% accuracy on a cell-by-cell basis with control data returning 54% accuracy (P 50nm) were most predictive. Electron microscopy revealed that they were primarily localized to the limiting membrane of multivesicular bodies (MVB). Many smaller dimers/multimers (d<50nm) were found on intraluminal vesicles within MVBs, providing a likely explanation for reduced pMAPK in those cells." @default.
- W2496092771 created "2016-08-23" @default.
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- W2496092771 date "2016-02-01" @default.
- W2496092771 modified "2023-09-30" @default.
- W2496092771 title "Probing the Non-Genetic Cell-To-Cell Heterogeneity in EGFR-Mediated MAPK Activation by Super-Resolution Microscopy" @default.
- W2496092771 doi "https://doi.org/10.1016/j.bpj.2015.11.2842" @default.
- W2496092771 hasPublicationYear "2016" @default.
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