Matches in SemOpenAlex for { <https://semopenalex.org/work/W2496116834> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2496116834 abstract "Abstract Objectives: We recently identified the ratio between absolute neutrophils count and absolute lymphocyte count, NLR ≥2, as a predictor of progression free survival (PFS) and overall survival (OS) in patients younger than 65 years with symptomatic Multiple Myeloma (MM). We retrospectively examined the NLR in a cohort of 140 smoldering Myeloma (sMM) defined accordingly to the updated IMWG 2014 guidelines accessed our Center between June 2006 and June 2014. Methods: NLR was calculated using data obtained from the complete blood count (CBC) at diagnosis and subsequently correlated with time to treatment (TTT) for symptomatic MM. All patients underwent bone marrow evaluation to estimate plasma cells infiltration (BMPC), Magnetic Resonance Imaging (MRI) to detect bone lesions, serum free-lite chain evaluation (sFLC) starting from January 2012 when they became evaluable in our center. Results: The mean NLR was 2.0 ± 0.1, lower than the value previously found for MM (2.7 ± 0.2, p= 0.005). Higher NLR was independent of BMPC amount, cytogenetics and sFLC. Using NLR ≥2 as predictive biomarker we could not predict TTT. In univariate analysis only BMPC ≥ 30% (p<0.0001), immunoparesis (suppression of one or more uninvolved immunoglobulins, p=0.017) and presence of at least one bone lesion at MRI (p<0.0001) could predict TTT. In multivariate analysis, these three parameters were independent (p<0.0001). Since new guidelines consider BMPC≥ 60% and positive MRI as myeloma-defining events, we proposed a simplified score model based on BMPC ≥ 30% (1 point) and immunoparesis (1 point). We identified patients with score 0 (20%) as low-risk (TTT at 60 months 0%), with score 1 (61%) as intermediate risk (TTT at 60 months 61%) and with score 2 as high-risk (TTT at 60 months 22%, p<0.0001). Conclusion: We confirmed BMPC and immunoparesis as strong predictors of outcome in sMM. Disclosures No relevant conflicts of interest to declare." @default.
- W2496116834 created "2016-08-23" @default.
- W2496116834 creator A5003679742 @default.
- W2496116834 creator A5018769545 @default.
- W2496116834 creator A5034393745 @default.
- W2496116834 creator A5060269287 @default.
- W2496116834 creator A5061788416 @default.
- W2496116834 creator A5062195312 @default.
- W2496116834 creator A5065852754 @default.
- W2496116834 date "2015-12-03" @default.
- W2496116834 modified "2023-09-26" @default.
- W2496116834 title "Plasmocytosis and Immunoparesis but Not Neutrophil to Lymphocyte Ratio Can Predict Time to Treatment in Smoldering Myeloma" @default.
- W2496116834 doi "https://doi.org/10.1182/blood.v126.23.5358.5358" @default.
- W2496116834 hasPublicationYear "2015" @default.
- W2496116834 type Work @default.
- W2496116834 sameAs 2496116834 @default.
- W2496116834 citedByCount "0" @default.
- W2496116834 crossrefType "journal-article" @default.
- W2496116834 hasAuthorship W2496116834A5003679742 @default.
- W2496116834 hasAuthorship W2496116834A5018769545 @default.
- W2496116834 hasAuthorship W2496116834A5034393745 @default.
- W2496116834 hasAuthorship W2496116834A5060269287 @default.
- W2496116834 hasAuthorship W2496116834A5061788416 @default.
- W2496116834 hasAuthorship W2496116834A5062195312 @default.
- W2496116834 hasAuthorship W2496116834A5065852754 @default.
- W2496116834 hasConcept C126322002 @default.
- W2496116834 hasConcept C141071460 @default.
- W2496116834 hasConcept C144301174 @default.
- W2496116834 hasConcept C2776364478 @default.
- W2496116834 hasConcept C2776694085 @default.
- W2496116834 hasConcept C2777063308 @default.
- W2496116834 hasConcept C2780007613 @default.
- W2496116834 hasConcept C2780739268 @default.
- W2496116834 hasConcept C3019894029 @default.
- W2496116834 hasConcept C38180746 @default.
- W2496116834 hasConcept C71924100 @default.
- W2496116834 hasConcept C72563966 @default.
- W2496116834 hasConcept C74133956 @default.
- W2496116834 hasConcept C90924648 @default.
- W2496116834 hasConceptScore W2496116834C126322002 @default.
- W2496116834 hasConceptScore W2496116834C141071460 @default.
- W2496116834 hasConceptScore W2496116834C144301174 @default.
- W2496116834 hasConceptScore W2496116834C2776364478 @default.
- W2496116834 hasConceptScore W2496116834C2776694085 @default.
- W2496116834 hasConceptScore W2496116834C2777063308 @default.
- W2496116834 hasConceptScore W2496116834C2780007613 @default.
- W2496116834 hasConceptScore W2496116834C2780739268 @default.
- W2496116834 hasConceptScore W2496116834C3019894029 @default.
- W2496116834 hasConceptScore W2496116834C38180746 @default.
- W2496116834 hasConceptScore W2496116834C71924100 @default.
- W2496116834 hasConceptScore W2496116834C72563966 @default.
- W2496116834 hasConceptScore W2496116834C74133956 @default.
- W2496116834 hasConceptScore W2496116834C90924648 @default.
- W2496116834 hasLocation W24961168341 @default.
- W2496116834 hasOpenAccess W2496116834 @default.
- W2496116834 hasPrimaryLocation W24961168341 @default.
- W2496116834 hasRelatedWork W2001500533 @default.
- W2496116834 hasRelatedWork W2043427586 @default.
- W2496116834 hasRelatedWork W2229743977 @default.
- W2496116834 hasRelatedWork W2238542946 @default.
- W2496116834 hasRelatedWork W2295848845 @default.
- W2496116834 hasRelatedWork W2336852897 @default.
- W2496116834 hasRelatedWork W2513660003 @default.
- W2496116834 hasRelatedWork W2801811842 @default.
- W2496116834 hasRelatedWork W2811403956 @default.
- W2496116834 hasRelatedWork W3082807652 @default.
- W2496116834 hasRelatedWork W3083702054 @default.
- W2496116834 hasRelatedWork W3123992430 @default.
- W2496116834 hasRelatedWork W3127538603 @default.
- W2496116834 hasRelatedWork W3148309641 @default.
- W2496116834 hasRelatedWork W3164363592 @default.
- W2496116834 hasRelatedWork W3167238655 @default.
- W2496116834 hasRelatedWork W3174185860 @default.
- W2496116834 hasRelatedWork W3194713905 @default.
- W2496116834 hasRelatedWork W3200393129 @default.
- W2496116834 hasRelatedWork W3201718986 @default.
- W2496116834 isParatext "false" @default.
- W2496116834 isRetracted "false" @default.
- W2496116834 magId "2496116834" @default.
- W2496116834 workType "article" @default.