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- W2496171922 abstract "The ability to depict and decipher the cues and reactions which drive the host response is of utmost importance to the safety and efficacy of biomaterial implants. Although many cell culture models have been developed to decipher the molecular mechanisms of cellular responses, animal testing remains to be the most reliable system to simulate complex cellular and tissue responses to the implants. Unfortunately, traditional histological evaluation used in animal studies is unable to identify the dynamic interplay between different cell types. Here in, we present several strategies to real-time evaluate and monitor host reactions, such as fibrin deposition, production of reactive oxygen species, pH changes, and macrophage polarity. With continued development, these methods may offer rapid, diverse, noninvasive, and cost-effective options to study and improve the design of devices and treatments with minimal adverse host reactions." @default.
- W2496171922 created "2016-08-23" @default.
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- W2496171922 date "2015-01-01" @default.
- W2496171922 modified "2023-09-22" @default.
- W2496171922 title "Methods Used to Evaluate the Host Responses to Medical Implants In Vivo" @default.
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- W2496171922 doi "https://doi.org/10.1016/b978-0-12-800196-7.00014-1" @default.
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