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- W2496181872 abstract "F-box proteins constitute a large superfamily in plants and play important roles in controlling many biological processes, but the roles of F-box proteins in male meiosis in plants remain unclear. Here, we identify the rice (Oryza sativa) F-box gene MEIOTIC F-BOX (MOF), which is essential for male meiotic progression. MOF belongs to the FBX subfamily and is predominantly active during leptotene to pachytene of prophase I. mof meiocytes display disrupted telomere bouquet formation, impaired pairing and synapsis of homologous chromosomes, and arrested meiocytes at late prophase I, followed by apoptosis. Although normal, programmed double-stranded DNA breaks (DSBs) form in mof mutants, foci of the phosphorylated histone variant γH2AX, a marker for DSBs, persist in the mutant, indicating that many of the DSBs remained unrepaired. The recruitment of Completion of meiosis I (COM1) and Radiation sensitive51C (RAD51C) to DSBs is severely compromised in mutant meiocytes, indicating that MOF is crucial for DSB end-processing and repair. Further analyses showed that MOF could physically interact with the rice SKP1-like Protein1 (OSK1), indicating that MOF functions as a component of the SCF E3 ligase to regulate meiotic progression in rice. Thus, this study reveals the essential role of an F-box protein in plant meiosis and provides helpful information for elucidating the roles of the ubiquitin proteasome system in plant meiotic progression." @default.
- W2496181872 created "2016-08-23" @default.
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- W2496181872 date "2016-07-19" @default.
- W2496181872 modified "2023-10-16" @default.
- W2496181872 title "MEIOTIC F-BOX Is Essential for Male Meiotic DNA Double-Strand Break Repair in Rice" @default.
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- W2496181872 doi "https://doi.org/10.1105/tpc.16.00108" @default.
- W2496181872 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5006700" @default.
- W2496181872 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27436711" @default.
- W2496181872 hasPublicationYear "2016" @default.