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• W2496222016 abstract "Background: Follistatin-like 3 is an extracellular regulator of the TGF-β superfamily members such as activin A, myostatin, and BMP2. FSTL-3 transcripts have been found to be upregulated in myocardium from patients with severe heart failure (HF), and are associated with severity of the disease. Furthermore, FSTL-3 has been identified as a possible modulator of stress-induced cardiac hypertrophy following pressure overload in mice. In this study, we sought to examine whether: 1) FSTL-3 is elevated in patients with HF vs. age-matched controls, and 2) FSTL-3 is elevated in patients with acute decompensated HF vs. those with chronic HF; and 3) FSTL-3 levels change 5 weeks after an acute HF episode. Methods and Results: We measured plasma levels of FSLT-3 in: 1) healthy ageing volunteers (n=67, age 68±6 yrs), 2) patients with acute HF (n=24, age 70±12), and 3) patients with chronic HF (n=28, age 71±9). Plasma FSTL-3 levels were significantly higher in both acute HF (median 11,635 pg/mL), and chronic HF (median 8916 pg/mL) patients, vs. healthy ageing volunteers (median 5463 pg/ml) (p<0.01 for both groups, Mann-U-Whitney) (Figure 1A). While there was no significant difference in NT-proBNP levels in between those with acute HF (mean ± SD (5123 ± 6645 pg/mL), vs. those with chronic HF (mean ± SD, 3485 ± 6423 pg/mL) (p=0.4, unpaired t-test); patients with chronic HF had significantly lower FSTL-3 levels vs. those with acute HF (p<0.05, Mann-U-Whitney) (Figure 1B). There was no difference in NT-proBNP levels in patients with acute HF upon admission vs. 5 weeks of follow-up, (mean ± SD, 3206 ± 2748) (p=0.2, unpaired t-test); with a trend towards lowering of FSTL-3 levels (mean ±SD, 13,131 ± 6621 pg/mL vs. 11,870 ± 4727 pg/mL, p=0.08, unpaired t-test). Conclusions: In this study, we observed that plasma levels of FSTL-3 are increased in HF patients. Acute HF patients appear to have incremental increase in FSTL-3 levels compared to those at chronic state, independent of NT-proBNP differences. These results suggest that FSTL-3 is a potential sensitive biomarker to detect changes in HF, prior to changes in NT-proBNP." @default.
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• W2496222016 date "2016-08-01" @default.
• W2496222016 modified "2023-09-27" @default.
• W2496222016 title "Follistatin-like 3 is Elevated in Acute Heart Failure Patients" @default.
• W2496222016 doi "https://doi.org/10.1016/j.hlc.2016.06.260" @default.
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