FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2496257712> ?p ?o ?g. }

• W2496257712 endingPage "5975" @default.
• W2496257712 startingPage "5968" @default.
• W2496257712 abstract "ABSTRACT Staphylococci are a leading cause of catheter-related infections (CRIs) due to biofilm formation. CRIs are typically managed by either device removal or systemic antibiotics, often in combination with catheter lock solutions (CLSs). CLSs provide high concentrations of the antimicrobial agent at the site of infection. However, the most effective CLSs against staphylococcal biofilm-associated infections have yet to be determined. The purpose of this study was to evaluate the efficacy and suitability of two newly described antimicrobial agents, ML:8 and Citrox, as CLSs against Staphylococcus aureus biofilms. ML:8 (1% [vol/vol]) and Citrox (1% [vol/vol]), containing caprylic acid and flavonoids, respectively, were used to treat S. aureus biofilms grown in vitro using newly described static and flow biofilm assays. Both agents reduced biofilm viability >97% after 24 h of treatment. Using a rat model of CRI, ML:8 was shown to inactivate early-stage S. aureus biofilms in vivo , while Citrox inactivated established, mature in vivo biofilms. Cytotoxicity and hemolytic activity of ML:8 and Citrox were equivalent to those of other commercially available CLSs. Neither ML:8 nor Citrox induced a cytokine response in human whole blood, and exposure of S. aureus to either agent for 90 days was not associated with any increase in resistance. Taken together, these data reveal the therapeutic potential of these agents for the treatment of S. aureus catheter-related biofilm infections." @default.
• W2496257712 created "2016-08-23" @default.
• W2496257712 creator A5005773706 @default.
• W2496257712 creator A5019032222 @default.
• W2496257712 creator A5028527006 @default.
• W2496257712 creator A5066232739 @default.
• W2496257712 creator A5081903810 @default.
• W2496257712 creator A5087289174 @default.
• W2496257712 date "2016-10-01" @default.
• W2496257712 modified "2023-10-01" @default.
• W2496257712 title "Eradication of Staphylococcus aureus Catheter-Related Biofilm Infections Using ML:8 and Citrox" @default.
• W2496257712 cites W1517638146 @default.
• W2496257712 cites W1521812393 @default.
• W2496257712 cites W187076603 @default.
• W2496257712 cites W1899719674 @default.
• W2496257712 cites W1995105203 @default.
• W2496257712 cites W2038924596 @default.
• W2496257712 cites W2040344295 @default.
• W2496257712 cites W2051695178 @default.
• W2496257712 cites W2054967201 @default.
• W2496257712 cites W2065448123 @default.
• W2496257712 cites W2076683402 @default.
• W2496257712 cites W2084765866 @default.
• W2496257712 cites W2087494894 @default.
• W2496257712 cites W2096592179 @default.
• W2496257712 cites W2097786095 @default.
• W2496257712 cites W2098785211 @default.
• W2496257712 cites W2106538205 @default.
• W2496257712 cites W2107524358 @default.
• W2496257712 cites W2111154143 @default.
• W2496257712 cites W2112785877 @default.
• W2496257712 cites W2114839157 @default.
• W2496257712 cites W2127113854 @default.
• W2496257712 cites W2133779402 @default.
• W2496257712 cites W2137426007 @default.
• W2496257712 cites W2138571667 @default.
• W2496257712 cites W2145480034 @default.
• W2496257712 cites W2157220975 @default.
• W2496257712 cites W2166118952 @default.
• W2496257712 cites W2166356134 @default.
• W2496257712 cites W2167110583 @default.
• W2496257712 cites W2172074295 @default.
• W2496257712 cites W2289532539 @default.
• W2496257712 cites W2407136586 @default.
• W2496257712 cites W2419239176 @default.
• W2496257712 doi "https://doi.org/10.1128/aac.00910-16" @default.
• W2496257712 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5038274" @default.
• W2496257712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27458213" @default.
• W2496257712 hasPublicationYear "2016" @default.
• W2496257712 type Work @default.
• W2496257712 sameAs 2496257712 @default.
• W2496257712 citedByCount "15" @default.
• W2496257712 countsByYear W24962577122018 @default.
• W2496257712 countsByYear W24962577122019 @default.
• W2496257712 countsByYear W24962577122020 @default.
• W2496257712 countsByYear W24962577122021 @default.
• W2496257712 countsByYear W24962577122022 @default.
• W2496257712 countsByYear W24962577122023 @default.
• W2496257712 crossrefType "journal-article" @default.
• W2496257712 hasAuthorship W2496257712A5005773706 @default.
• W2496257712 hasAuthorship W2496257712A5019032222 @default.
• W2496257712 hasAuthorship W2496257712A5028527006 @default.
• W2496257712 hasAuthorship W2496257712A5066232739 @default.
• W2496257712 hasAuthorship W2496257712A5081903810 @default.
• W2496257712 hasAuthorship W2496257712A5087289174 @default.
• W2496257712 hasBestOaLocation W24962577121 @default.
• W2496257712 hasConcept C141071460 @default.
• W2496257712 hasConcept C150903083 @default.
• W2496257712 hasConcept C185592680 @default.
• W2496257712 hasConcept C207001950 @default.
• W2496257712 hasConcept C2777052132 @default.
• W2496257712 hasConcept C2777334864 @default.
• W2496257712 hasConcept C2779489039 @default.
• W2496257712 hasConcept C2781267111 @default.
• W2496257712 hasConcept C4937899 @default.
• W2496257712 hasConcept C501593827 @default.
• W2496257712 hasConcept C523546767 @default.
• W2496257712 hasConcept C54355233 @default.
• W2496257712 hasConcept C58123911 @default.
• W2496257712 hasConcept C71924100 @default.
• W2496257712 hasConcept C86803240 @default.
• W2496257712 hasConcept C89423630 @default.
• W2496257712 hasConceptScore W2496257712C141071460 @default.
• W2496257712 hasConceptScore W2496257712C150903083 @default.
• W2496257712 hasConceptScore W2496257712C185592680 @default.
• W2496257712 hasConceptScore W2496257712C207001950 @default.
• W2496257712 hasConceptScore W2496257712C2777052132 @default.
• W2496257712 hasConceptScore W2496257712C2777334864 @default.
• W2496257712 hasConceptScore W2496257712C2779489039 @default.
• W2496257712 hasConceptScore W2496257712C2781267111 @default.
• W2496257712 hasConceptScore W2496257712C4937899 @default.
• W2496257712 hasConceptScore W2496257712C501593827 @default.
• W2496257712 hasConceptScore W2496257712C523546767 @default.
• W2496257712 hasConceptScore W2496257712C54355233 @default.
• W2496257712 hasConceptScore W2496257712C58123911 @default.
• W2496257712 hasConceptScore W2496257712C71924100 @default.
• W2496257712 hasConceptScore W2496257712C86803240 @default.
• W2496257712 hasConceptScore W2496257712C89423630 @default.

• next