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- W2496278052 abstract "The production of pesticide specific antibodies requires presentation of a conjugated form of the pesticide to an animal's immune system. This in turn demands the design of an appropriate chemical structure (a hapten) which can be covalently coupled to a carrier, but which will still elicit the production of antibodies recognizing the target analyte. The immunoassay literature does not adequately address the question of what chemical structure is required for the production of specific antibodies to low molecular weight compounds, especially in the pesticide area. Hapten design historically is considered an art, with minimal or no explanation for hapten structures which failed to produce the desired antibodies. Most failed attempts remain unpublished and thus have not shed light on the structural requirements for antibody production. We present here an examination of selected examples of successful and unsuccessful hapten designs from our laboratory and from the literature. These examples are used herein to illustrate several criteria deemed critical for successful hapten synthesis strategies." @default.
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- W2496278052 date "1990-12-26" @default.
- W2496278052 modified "2023-10-12" @default.
- W2496278052 title "Hapten Synthesis for Pesticide Immunoassay Development" @default.
- W2496278052 doi "https://doi.org/10.1021/bk-1990-0451.ch002" @default.
- W2496278052 hasPublicationYear "1990" @default.
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