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• W2496289375 abstract "Governing the biomaterial mediated tissue response is critically importance for the future design and improvement of many medical implants. As such, an enormous amount of research effort has been placed on seeking a means to alter or control implant associated tissue reactions. Ultimately, the numerous strategies attempted boil down to a single notion of manipulating proteins and cells at the material interface. While the mechanisms and processes governing such reactions are not entirely understood, surface modification techniques have become the primary strategy, encompassing a wide variety of methods to improve the biomaterial interaction. While methods such as surface chemistry, functionality, and hydophobicity have all lead to various degrees of improvement, surface topography may be the largest contributor to combat adverse tissue and cellular reactions. We focus our discussion on the recent advances of surface topography manipulation and its effect on specific cellular responses both in vitro and in vivo. In particular we and others have found that micropillar topography has a profound effect on cellular morphology, migration, differentiation, and expression in vitro. The resultant influence of micropillar arrays on tissue responses in vivo however have only just begun to be investigated. Surprisingly, our own research has revealed that fibrocytes, circulating fibroblasts, but not macrophages are mostly responsible for micropillar-mediated tissue responses in vivo. A better understanding of the interactions between fibrocytes and micropillar topography may provide critical information for improving implant safety and function." @default.
• W2496289375 created "2016-08-23" @default.
• W2496289375 creator A5000863621 @default.
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• W2496289375 date "2012-01-01" @default.
• W2496289375 modified "2023-09-24" @default.
• W2496289375 title "Effect of Microtopography on Fibrocyte Responses and Fibrotic Tissue Reactions at the Interface" @default.
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• W2496289375 doi "https://doi.org/10.1021/bk-2012-1120.ch015" @default.
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