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- W2496341346 abstract "Background: Periodontitis is an inflammatory destruction of periodontal tissue associated with cytokine dysfunctions. Objectives:To check for the association of polymorphisms of cytokine genes with the susceptibility and severity of Periodontitis in cases from Egypt. Subjects: 46 cases with periodontitis in addition to 98 healthy unrelated controls. Cases were classified into aggressive or early onset periodontitis (EOP) (17 cases, 36.9%) and chronic or adult onset periodontitis (AOP) (29 cases, 63.1%). Methods: DNA was amplified using PCR-SSP for detection of polymorphisms related to TNF-α -308 (G/A), IL-10 -1082 (G/A), IL-6 -174 (G/C) and IL-1Ra (VNTR). Results: Total cases showed high significant frequency of homozygous IL-10 -1082 (A/A) (OR=3.97, P<0.05), TNF-α -308 (G/G) (OR=6.71, P<0.001), IL-6 -174 C/C (OR=8.18, P<0.001) and IL-1Ra (A1/A1) (OR=3.42, P<0.05) genotypes. These were considered risk genotypes for disease susceptibility. The same was shown AOP cases while EOP cases showed only high significant frequency of homozygous IL-6 -174 (C/C) (OR=8.36, P<0.05) and TNF-α -308 (G/G) (OR=4.72, P<0.05) genotypes. On the other hand, combined heterozygosity for IL-10 -1082 (G/A) with TNF-α -308 (G/A) showed lowest significant frequency among all cases (P<0.001) and were considered low risk genotypes. Conclusions: Cytokine gene polymorphisms may be used as a marker for periodontitis susceptibility, and severity helping for early diagnosis and induction of prophylaxis to affected families." @default.
- W2496341346 created "2016-08-23" @default.
- W2496341346 date "2006-01-01" @default.
- W2496341346 modified "2023-09-26" @default.
- W2496341346 title "Gene Polymorphisms of TNF-α<sup>-308</sup>(G/A), IL-10<sup>-1082</sup>(G/A), IL6<sup>-174</sup>(G/C) and IL1Ra(VNTR) in Egyptian Cases with Adult and Early Onset Periodontitis" @default.
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- W2496341346 doi "https://doi.org/10.5580/1194" @default.
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