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- W2496348854 abstract "Indomethacin microemulsion loaded chitosan microspheres (IMCMs) were prepared by a spray-drying technique. IMCMs were spheroids formed by aggregates of microspheres with sizes of ~8 µm, while indomethacin loaded chitosan microspheres (ICM) (control) did not show any agglomeration. Indomethacin (IDM) appeared to be in an amorphous state in both ICMs and IMCMs, confirmed by X-ray diffraction and differential scanning calorimetry. The encapsulation efficiency of IDM was higher in IMCM than ICM. IMCMs exhibited a pH independent and sustained release pattern with small burst effect, compared to ICMs. Thus, drug-in-microemulsion loaded polymeric microspheres could possibly provide a sustained release formulation." @default.
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- W2496348854 date "2008-11-07" @default.
- W2496348854 modified "2023-09-27" @default.
- W2496348854 title "Controlled Release of Indomethacin from Spray-Dried Chitosan Microspheres Containing Microemulsion" @default.
- W2496348854 doi "https://doi.org/10.1021/bk-2008-0992.ch004" @default.
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