FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2496372198> ?p ?o ?g. }

• W2496372198 endingPage "e0159528" @default.
• W2496372198 startingPage "e0159528" @default.
• W2496372198 abstract "Agonist-activated G protein-coupled receptors (GPCRs) interact with GDP-bound G protein heterotrimers (Gαβγ) promoting GDP/GTP exchange, which results in dissociation of Gα from the receptor and Gβγ. The GTPase activity of Gα hydrolyzes GTP to GDP, and the GDP-bound Gα interacts with Gβγ, forming a GDP-bound G protein heterotrimer. The G protein cycle is allosterically modulated by conformational changes of the Gα subunit. Although biochemical and biophysical methods have elucidated the structure and dynamics of Gα, the precise conformational mechanisms underlying the G protein cycle are not fully understood yet. Simulation methods could help to provide additional details to gain further insight into G protein signal transduction mechanisms. In this study, using the available X-ray crystal structures of Gα, we simulated the entire G protein cycle and described not only the steric features of the Gα structure, but also conformational changes at each step. Each reference structure in the G protein cycle was modeled as an elastic network model and subjected to normal mode analysis. Our simulation data suggests that activated receptors trigger conformational changes of the Gα subunit that are thermodynamically favorable for opening of the nucleotide-binding pocket and GDP release. Furthermore, the effects of GTP binding and hydrolysis on mobility changes of the C and N termini and switch regions are elucidated. In summary, our simulation results enabled us to provide detailed descriptions of the structural and dynamic features of the G protein cycle." @default.
• W2496372198 created "2016-08-23" @default.
• W2496372198 creator A5016794944 @default.
• W2496372198 creator A5021230218 @default.
• W2496372198 creator A5044134935 @default.
• W2496372198 creator A5048901399 @default.
• W2496372198 creator A5057167550 @default.
• W2496372198 creator A5071852246 @default.
• W2496372198 creator A5079184638 @default.
• W2496372198 date "2016-08-02" @default.
• W2496372198 modified "2023-09-23" @default.
• W2496372198 title "Computational Simulation of the Activation Cycle of Gα Subunit in the G Protein Cycle Using an Elastic Network Model" @default.
• W2496372198 cites W1199870172 @default.
• W2496372198 cites W1560061125 @default.
• W2496372198 cites W1580353693 @default.
• W2496372198 cites W1942777601 @default.
• W2496372198 cites W1968407616 @default.
• W2496372198 cites W1970961331 @default.
• W2496372198 cites W1972760976 @default.
• W2496372198 cites W1973834037 @default.
• W2496372198 cites W1977314934 @default.
• W2496372198 cites W1984702729 @default.
• W2496372198 cites W1989222688 @default.
• W2496372198 cites W1990457307 @default.
• W2496372198 cites W1993466966 @default.
• W2496372198 cites W1993523190 @default.
• W2496372198 cites W1994953274 @default.
• W2496372198 cites W1998132407 @default.
• W2496372198 cites W1998158537 @default.
• W2496372198 cites W2001449162 @default.
• W2496372198 cites W2004125744 @default.
• W2496372198 cites W2009192117 @default.
• W2496372198 cites W2010291063 @default.
• W2496372198 cites W2010544588 @default.
• W2496372198 cites W2012770242 @default.
• W2496372198 cites W2015176049 @default.
• W2496372198 cites W2015642465 @default.
• W2496372198 cites W2016441306 @default.
• W2496372198 cites W2020878965 @default.
• W2496372198 cites W2021008077 @default.
• W2496372198 cites W2022754746 @default.
• W2496372198 cites W2023038974 @default.
• W2496372198 cites W2024850327 @default.
• W2496372198 cites W2030185192 @default.
• W2496372198 cites W2031340110 @default.
• W2496372198 cites W2044775506 @default.
• W2496372198 cites W2048822589 @default.
• W2496372198 cites W2052280808 @default.
• W2496372198 cites W2056261267 @default.
• W2496372198 cites W2062602712 @default.
• W2496372198 cites W2063962473 @default.
• W2496372198 cites W2064118841 @default.
• W2496372198 cites W2064664612 @default.
• W2496372198 cites W2064693369 @default.
• W2496372198 cites W2066962978 @default.
• W2496372198 cites W2070171539 @default.
• W2496372198 cites W2071152222 @default.
• W2496372198 cites W2090252012 @default.
• W2496372198 cites W2093626313 @default.
• W2496372198 cites W2103774849 @default.
• W2496372198 cites W2113862155 @default.
• W2496372198 cites W2123061927 @default.
• W2496372198 cites W2133220219 @default.
• W2496372198 cites W2136906322 @default.
• W2496372198 cites W2140686653 @default.
• W2496372198 cites W2145940857 @default.
• W2496372198 cites W2160573688 @default.
• W2496372198 cites W2167857702 @default.
• W2496372198 cites W2174040158 @default.
• W2496372198 cites W2274505228 @default.
• W2496372198 cites W50079648 @default.
• W2496372198 doi "https://doi.org/10.1371/journal.pone.0159528" @default.
• W2496372198 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4970668" @default.
• W2496372198 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27483005" @default.
• W2496372198 hasPublicationYear "2016" @default.
• W2496372198 type Work @default.
• W2496372198 sameAs 2496372198 @default.
• W2496372198 citedByCount "3" @default.
• W2496372198 countsByYear W24963721982018 @default.
• W2496372198 countsByYear W24963721982020 @default.
• W2496372198 crossrefType "journal-article" @default.
• W2496372198 hasAuthorship W2496372198A5016794944 @default.
• W2496372198 hasAuthorship W2496372198A5021230218 @default.
• W2496372198 hasAuthorship W2496372198A5044134935 @default.
• W2496372198 hasAuthorship W2496372198A5048901399 @default.
• W2496372198 hasAuthorship W2496372198A5057167550 @default.
• W2496372198 hasAuthorship W2496372198A5071852246 @default.
• W2496372198 hasAuthorship W2496372198A5079184638 @default.
• W2496372198 hasBestOaLocation W24963721981 @default.
• W2496372198 hasConcept C104292427 @default.
• W2496372198 hasConcept C104317684 @default.
• W2496372198 hasConcept C118716 @default.
• W2496372198 hasConcept C12554922 @default.
• W2496372198 hasConcept C135285700 @default.
• W2496372198 hasConcept C147597530 @default.
• W2496372198 hasConcept C166342909 @default.
• W2496372198 hasConcept C170493617 @default.
• W2496372198 hasConcept C181199279 @default.

• next