Matches in SemOpenAlex for { <https://semopenalex.org/work/W2496396069> ?p ?o ?g. }
- W2496396069 abstract "Abstract Neurohormonal mediators play a critical role in adverse cardiac remodeling in heart failure (HF) and ischemic heart diseases, and thus they represent pivotal targets for treatment. In particular, aldosterone has recently emerged as a terminal and crucial effector of renin-angiotensin-aldosterone system, strongly promoting both vascular inflammation and cardiac fibrosis. Currently, only two drugs are approved for clinical use in patients with HF: spironolactone and eplerenone. Several experimental and clinical trials showed the effectiveness and safety of these medications in systolic HF. On the other hand, additional clinical trials are required to confirm a protective role in HF with preserved ejection fraction as well as in preventing arrhythmias. Some concerns remain about the risk of hyperkalemia and the incidence of progesterone/antiandrogenic side effects, due to a close homology between the different steroidal receptors. The aim of this narrative review is to update evidence on the pharmacological aspects and clinical use of mineralcorticoid receptor antagonists, focusing on their different selectivity toward mineralcorticoid receptor and possibly cardiac tissue." @default.
- W2496396069 created "2016-08-23" @default.
- W2496396069 creator A5024812334 @default.
- W2496396069 creator A5056252884 @default.
- W2496396069 date "2015-01-01" @default.
- W2496396069 modified "2023-09-23" @default.
- W2496396069 title "Mineralcorticoid Receptor Antagonists" @default.
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