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- W2496650515 abstract "Significance Malignant cells of breast carcinoma and nonmalignant epithelia of branching mammary glands share the ability to migrate through their surroundings. To form the mammary tree-like architecture, nonmalignant epithelia must migrate in a controlled fashion, integrating cues from their microenvironment, notably, the glycan appendages on extracellular proteins and lipids. Here, we show that Galectin-1, a glycan-binding protein, is able to sense glycan signatures on mammary gland epithelia, transmit this information to epithelial nuclei by direct translocation, and drive branching migration. Nuclear galectin-1 is regulated by the relative levels of α2,6–sialic acids and N -acetyllactosamine on extracellular glycans. Similar lectin–glycan signatures were observed in malignant breast cells and suggest cancer cells use this pathway during their invasion." @default.
- W2496650515 created "2016-08-23" @default.
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- W2496650515 date "2016-08-05" @default.
- W2496650515 modified "2023-10-10" @default.
- W2496650515 title "Nuclear repartitioning of galectin-1 by an extracellular glycan switch regulates mammary morphogenesis" @default.
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- W2496650515 doi "https://doi.org/10.1073/pnas.1609135113" @default.
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