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- W2496753898 abstract "Objective: To report a case of osmotic demyelination syndrome and rhabdomyolysis secondary to postpartum hypernatremia. Introduction: Extrapontine myelinolysis associated with metabolic abnormalities especially hypernatremia is extremely rare disorder. Osmotic demyelination syndrome resulting from postpartum hypernatremia is recently described entity (2010) whereyoung women present with hypernatremic encephalopathy, quadriparesis and rhabdomyolysis with myelinolysis on imaging. Case report: A 20 year-old lady presentedwith fever and disorientation of 5 days and generalized tonic clonic seizures of 1-day duration. She had undergone a lower segment caesarean section3 weeks prior to this and had an uneventful postoperative periodand was keeping well for next 1 week.On examination she wasfebrile, vitals were stable, but was drowsy, flexing limbs and opening eyes to pain, with no verbal response. Limbs were flaccid; areflexic and plantarreflexes were unresponsive. Biochemical evaluation revealed asodium level of 182meq/l, (creatine phosphokinase) CPK -2207 U/L,urea-135mg/dl, andcreatinine-4.3mg/dl.MRI brain showed T2/FLAIR hyper intensities in tail and isthmus of hippocampus, bilateral basal ganglia, middle cerebellar peduncles,posterior limb ofinternal capsule,and subcortical white matter suggestive of extrapontine myelinoysis. Patient underwent correction of metabolic abnormalities however progressively worsened in sensorium and motor weakness and succumbed to her illness over next 7 days. Discussion and Conclusion: Clinicians must be aware of this entity of postpartum hypernatremia due to water restriction and diabetes insipidus. The metabolic abnormalityshould be looked for and treated at the earliest, as mortality remains high (>50[percnt]). Disclosure: Dr. Raghavan M.S has nothing to disclose. Dr. Archana N.B. has nothing to disclose. Dr. Agadi has nothing to disclose. Dr. Karthik has nothing to disclose. Dr. Deepak has nothing to disclose." @default.
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- W2496753898 date "2016-04-05" @default.
- W2496753898 modified "2023-09-26" @default.
- W2496753898 title "Osmotic Demyelination Syndrome and Rhabdomyolysis Secondary to Postpartum Hypernatremia (P4.398)" @default.
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