FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2496812908> ?p ?o ?g. }

• W2496812908 endingPage "1992" @default.
• W2496812908 startingPage "1987" @default.
• W2496812908 abstract "Objective. Alterations in phenotype and function of endothelial progenitor cells (EPCs) have been associated with poor vascular outcomes and impaired vascular repair in various conditions. Our hypothesis was that patients with PM and DM have dysregulation of EPCs driven by type I IFN and IL-18 similar to other autoimmune diseases. Methods. Quantification of circulating EPCs was performed by flow cytometry in patients with PM/DM and matched healthy controls. The ability of EPCs to differentiate into mature endothelial cells was investigated by light and fluorescence microscopy quantification in the presence or absence of PM/DM or control serum, neutralizing antibodies to type I IFN receptor or IL-18. Serum type I IFN activity was quantified by induction of type I IFN-inducible genes in HeLa cells. Circulating IL-18 concentrations were assessed by ELISA. Results. Circulating EPCs were significantly lower in PM/DM patients compared with controls. PM/DM EPCs displayed a decreased capacity to differentiate into mature endothelial cells and PM/DM serum significantly inhibited differentiation of control EPCs. This effect was reversed in the majority of samples with neutralizing antibodies to IL-18 or to type I IFN receptor or by a combination of these antibodies. Patients with associated impairments in EPC function had higher type I IFN serum activity. Conclusion. PM/DM is associated with dysregulation of EPC phenotype and function that may be attributed, at least in part, to aberrant IL-18 and type I IFN pathways. The implication of these vasculopathic findings for disease prognosis and complications remains to be determined." @default.
• W2496812908 created "2016-08-23" @default.
• W2496812908 creator A5010407321 @default.
• W2496812908 creator A5011002229 @default.
• W2496812908 creator A5018164973 @default.
• W2496812908 creator A5018663852 @default.
• W2496812908 creator A5027379087 @default.
• W2496812908 creator A5037527485 @default.
• W2496812908 creator A5040865874 @default.
• W2496812908 creator A5059480767 @default.
• W2496812908 creator A5062407111 @default.
• W2496812908 creator A5064435783 @default.
• W2496812908 date "2016-08-07" @default.
• W2496812908 modified "2023-10-10" @default.
• W2496812908 title "Dysfunction of endothelial progenitor cells is associated with the type I IFN pathway in patients with polymyositis and dermatomyositis" @default.
• W2496812908 cites W1699876092 @default.
• W2496812908 cites W1855653050 @default.
• W2496812908 cites W1972060594 @default.
• W2496812908 cites W2025874285 @default.
• W2496812908 cites W2026506549 @default.
• W2496812908 cites W2072328028 @default.
• W2496812908 cites W2098715000 @default.
• W2496812908 cites W2121591722 @default.
• W2496812908 cites W2122995291 @default.
• W2496812908 cites W2141062312 @default.
• W2496812908 cites W2151403954 @default.
• W2496812908 cites W2151463001 @default.
• W2496812908 cites W2154079282 @default.
• W2496812908 cites W2154579584 @default.
• W2496812908 cites W2314311014 @default.
• W2496812908 doi "https://doi.org/10.1093/rheumatology/kew288" @default.
• W2496812908 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5088625" @default.
• W2496812908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27498356" @default.
• W2496812908 hasPublicationYear "2016" @default.
• W2496812908 type Work @default.
• W2496812908 sameAs 2496812908 @default.
• W2496812908 citedByCount "22" @default.
• W2496812908 countsByYear W24968129082017 @default.
• W2496812908 countsByYear W24968129082018 @default.
• W2496812908 countsByYear W24968129082019 @default.
• W2496812908 countsByYear W24968129082021 @default.
• W2496812908 countsByYear W24968129082022 @default.
• W2496812908 countsByYear W24968129082023 @default.
• W2496812908 crossrefType "journal-article" @default.
• W2496812908 hasAuthorship W2496812908A5010407321 @default.
• W2496812908 hasAuthorship W2496812908A5011002229 @default.
• W2496812908 hasAuthorship W2496812908A5018164973 @default.
• W2496812908 hasAuthorship W2496812908A5018663852 @default.
• W2496812908 hasAuthorship W2496812908A5027379087 @default.
• W2496812908 hasAuthorship W2496812908A5037527485 @default.
• W2496812908 hasAuthorship W2496812908A5040865874 @default.
• W2496812908 hasAuthorship W2496812908A5059480767 @default.
• W2496812908 hasAuthorship W2496812908A5062407111 @default.
• W2496812908 hasAuthorship W2496812908A5064435783 @default.
• W2496812908 hasBestOaLocation W24968129081 @default.
• W2496812908 hasConcept C104317684 @default.
• W2496812908 hasConcept C126322002 @default.
• W2496812908 hasConcept C127716648 @default.
• W2496812908 hasConcept C159654299 @default.
• W2496812908 hasConcept C201750760 @default.
• W2496812908 hasConcept C203014093 @default.
• W2496812908 hasConcept C2778751314 @default.
• W2496812908 hasConcept C2779387793 @default.
• W2496812908 hasConcept C2780152582 @default.
• W2496812908 hasConcept C28328180 @default.
• W2496812908 hasConcept C54355233 @default.
• W2496812908 hasConcept C553184892 @default.
• W2496812908 hasConcept C55493867 @default.
• W2496812908 hasConcept C71924100 @default.
• W2496812908 hasConcept C86803240 @default.
• W2496812908 hasConceptScore W2496812908C104317684 @default.
• W2496812908 hasConceptScore W2496812908C126322002 @default.
• W2496812908 hasConceptScore W2496812908C127716648 @default.
• W2496812908 hasConceptScore W2496812908C159654299 @default.
• W2496812908 hasConceptScore W2496812908C201750760 @default.
• W2496812908 hasConceptScore W2496812908C203014093 @default.
• W2496812908 hasConceptScore W2496812908C2778751314 @default.
• W2496812908 hasConceptScore W2496812908C2779387793 @default.
• W2496812908 hasConceptScore W2496812908C2780152582 @default.
• W2496812908 hasConceptScore W2496812908C28328180 @default.
• W2496812908 hasConceptScore W2496812908C54355233 @default.
• W2496812908 hasConceptScore W2496812908C553184892 @default.
• W2496812908 hasConceptScore W2496812908C55493867 @default.
• W2496812908 hasConceptScore W2496812908C71924100 @default.
• W2496812908 hasConceptScore W2496812908C86803240 @default.
• W2496812908 hasIssue "11" @default.
• W2496812908 hasLocation W24968129081 @default.
• W2496812908 hasLocation W24968129082 @default.
• W2496812908 hasLocation W24968129083 @default.
• W2496812908 hasLocation W24968129084 @default.
• W2496812908 hasLocation W24968129085 @default.
• W2496812908 hasLocation W24968129086 @default.
• W2496812908 hasLocation W24968129087 @default.
• W2496812908 hasOpenAccess W2496812908 @default.
• W2496812908 hasPrimaryLocation W24968129081 @default.
• W2496812908 hasRelatedWork W1013814 @default.
• W2496812908 hasRelatedWork W1984672571 @default.
• W2496812908 hasRelatedWork W2006120378 @default.

• next