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- W2496894978 abstract "This chapter focuses on the work that defines indoleamine 2,3-dioxygenase (IDO) as an important mediator of the peripheral tolerance. It provides the findings about the IDO dysregulation in cancer cells and explains the development of the anticancer modalities that employ the IDO inhibitors. Malignant development is accompanied by a breakdown of normal cellular physiology. This process involves the acquisition of cell-intrinsic traits, which includes immortalization, growth sufficiency, insensitivity to growth inhibitory signals, and apoptosis resistance, as well as the acquisition of cell-extrinsic traits—including angiogenesis, invasive capability, metastatic capacity, and immune escape. The immune escape is a terminal feature of immune-editing, which consists of surveillance, equilibrium, and escape of the tumor cells from effective control by the immune system. The survival benefit of this mechanism to a tumor cell is balanced by the cost of depriving itself of an essential amino acid. Immune escape has gained wide recognition among cancer geneticists as a crucial feature of malignant development." @default.
- W2496894978 created "2016-08-23" @default.
- W2496894978 creator A5063480688 @default.
- W2496894978 creator A5089381889 @default.
- W2496894978 date "2007-01-01" @default.
- W2496894978 modified "2023-09-26" @default.
- W2496894978 title "Indoleamine 2,3-Dioxygenase in Immune Escape: Regulation and Therapeutic Inhibition" @default.
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