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- W2496939751 abstract "A new series of pyrrolo[3',2':6,7]cyclohepta[1,2-d]pyrimidin-2-amines, was conveniently prepared using a versatile and high yielding multistep sequence. A good number of derivatives was obtained and the cellular photocytotoxicity was evaluated in vitro against three different human tumor cell lines with EC50 (0.08-4.96 μM) values reaching the nanomolar level. Selected compounds were investigated by laser flash photolysis. The most photocytotoxic derivative, exhibiting a fairly long-lived triplet state (τ ∼ 7 μs) and absorbance in the UV-Vis, was tested in the photo-oxidations of 9,10-anthracenedipropionic acid (ADPA) by singlet oxygen. The photosentizing properties are responsible for the compounds' ability to photoinduce massive cell death with involvement of mitochondria." @default.
- W2496939751 created "2016-08-23" @default.
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- W2496939751 date "2016-11-01" @default.
- W2496939751 modified "2023-10-16" @default.
- W2496939751 title "Synthesis and antiproliferative mechanism of action of pyrrolo[3′,2′:6,7] cyclohepta[1,2- d ]pyrimidin-2-amines as singlet oxygen photosensitizers" @default.
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- W2496939751 doi "https://doi.org/10.1016/j.ejmech.2016.07.051" @default.
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