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- W2497003890 startingPage "49" @default.
- W2497003890 abstract "Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) invariably arises from a background of chronic microbial infection and/or autoimmune disorder at diverse mucosal sites. The prolonged chronic infection and/or autoimmunity generate active immune and inflammatory responses that provide a setting for evolution and development of autoreactive B-cells, their expansion and eventual malignant transformation following acquisition of genetic changes. The immune responses also play a critical role in sustaining the growth and survival of the transformed cells as shown by complete regression of a high proportion of MALT lymphoma of the stomach, ocular adnexa and skin following anti-microbial treatment. B-cell receptor engagement by auto-antigen as well as T-cell help including both cognate interaction and bystander help via soluble ligands such as CD40L and BAFF are thought to underpin the immunological drive in the lymphoma development through activation of the canonical and non-canonical NF-κB pathway respectively. Similarly, the three MALT lymphoma associated chromosome translocations, namely t(1;14)(p22;q32)/BCL10-IGH, t(14;18)(q32;q21)/IGH-MALT1,and t(11;18)(q21;q21)/BIRC3 (API2)-MALT1, are also capable of activating both canonical and non-canonical NF-κB pathways. Furthermore, TNFAIP3 (A20) inactivation by deletion and/or mutation abolishes the auto-negative feedback to several signalling including BCR and TLR, which connect to the canonical NF-κB activation pathway. Thus, there is a considerable overlap in the molecular pathways dysregulated by immunological drive and somatic genetic changes, strongly arguing for their oncogenic cooperation in the development of MALT lymphoma." @default.
- W2497003890 created "2016-08-23" @default.
- W2497003890 creator A5002852999 @default.
- W2497003890 date "2016-08-01" @default.
- W2497003890 modified "2023-10-17" @default.
- W2497003890 title "MALT lymphoma: A paradigm of NF-κB dysregulation" @default.
- W2497003890 cites W1502055428 @default.
- W2497003890 cites W1520695706 @default.
- W2497003890 cites W1548460291 @default.
- W2497003890 cites W1554981631 @default.
- W2497003890 cites W1555550984 @default.
- W2497003890 cites W1563487810 @default.
- W2497003890 cites W1596938010 @default.
- W2497003890 cites W1607483353 @default.
- W2497003890 cites W1608909099 @default.
- W2497003890 cites W1630377425 @default.
- W2497003890 cites W174502258 @default.
- W2497003890 cites W1801682147 @default.
- W2497003890 cites W1816044327 @default.
- W2497003890 cites W1831727331 @default.
- W2497003890 cites W1900297117 @default.
- W2497003890 cites W1955888505 @default.
- W2497003890 cites W1965658052 @default.
- W2497003890 cites W1965742783 @default.
- W2497003890 cites W1966334174 @default.
- W2497003890 cites W1968799291 @default.
- W2497003890 cites W1971483434 @default.
- W2497003890 cites W1974030711 @default.
- W2497003890 cites W1976349384 @default.
- W2497003890 cites W1976590012 @default.
- W2497003890 cites W1979646611 @default.
- W2497003890 cites W1979771675 @default.
- W2497003890 cites W1983415264 @default.
- W2497003890 cites W1984255762 @default.
- W2497003890 cites W1984621574 @default.
- W2497003890 cites W1984785868 @default.
- W2497003890 cites W1986339942 @default.
- W2497003890 cites W1986385380 @default.
- W2497003890 cites W1986442376 @default.
- W2497003890 cites W1988476615 @default.
- W2497003890 cites W1990762111 @default.
- W2497003890 cites W1991559003 @default.
- W2497003890 cites W1992202416 @default.
- W2497003890 cites W1993361190 @default.
- W2497003890 cites W1996203901 @default.
- W2497003890 cites W1996305237 @default.
- W2497003890 cites W1998003228 @default.
- W2497003890 cites W2000102591 @default.
- W2497003890 cites W200132913 @default.
- W2497003890 cites W2005739512 @default.
- W2497003890 cites W2005946588 @default.
- W2497003890 cites W2006338784 @default.
- W2497003890 cites W2006987785 @default.
- W2497003890 cites W2008411546 @default.
- W2497003890 cites W2010459522 @default.
- W2497003890 cites W2010479391 @default.
- W2497003890 cites W2011236111 @default.
- W2497003890 cites W2013172787 @default.
- W2497003890 cites W2020045401 @default.
- W2497003890 cites W2023032337 @default.
- W2497003890 cites W2024991882 @default.
- W2497003890 cites W2028085984 @default.
- W2497003890 cites W2028882640 @default.
- W2497003890 cites W2030262603 @default.
- W2497003890 cites W2032388082 @default.
- W2497003890 cites W2033041235 @default.
- W2497003890 cites W2033734454 @default.
- W2497003890 cites W2034611537 @default.
- W2497003890 cites W2034927462 @default.
- W2497003890 cites W2035135710 @default.
- W2497003890 cites W2035231658 @default.
- W2497003890 cites W2035245019 @default.
- W2497003890 cites W2038426029 @default.
- W2497003890 cites W2038664197 @default.
- W2497003890 cites W2038710517 @default.
- W2497003890 cites W2040470196 @default.
- W2497003890 cites W2043801813 @default.
- W2497003890 cites W2045205786 @default.
- W2497003890 cites W2045539057 @default.
- W2497003890 cites W2046049693 @default.
- W2497003890 cites W2046862219 @default.
- W2497003890 cites W2048124929 @default.
- W2497003890 cites W2050469632 @default.
- W2497003890 cites W2055341066 @default.
- W2497003890 cites W2055573606 @default.
- W2497003890 cites W2056295465 @default.
- W2497003890 cites W2059378435 @default.
- W2497003890 cites W2059685005 @default.
- W2497003890 cites W2062130075 @default.
- W2497003890 cites W2063880348 @default.
- W2497003890 cites W2065116529 @default.
- W2497003890 cites W2067615866 @default.
- W2497003890 cites W2072717560 @default.
- W2497003890 cites W2075039650 @default.
- W2497003890 cites W2082414447 @default.
- W2497003890 cites W2083415414 @default.
- W2497003890 cites W2083498707 @default.
- W2497003890 cites W2085547602 @default.