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- W2497248081 abstract "Objectives Deep brain stimulation is an established therapy in various movement disorders. Recent pilot studies investigate the effect of DBS on cognition in Alzheimer Disease. Here we report the impact of DBS of the hippocampal formation on cognitive functions. Patients & Methods Two patients with GPi DBS for generalized dystonia or idiopathic orofacial dyskinesia (Meige Syndrome) were send to our university hospital for advanced reprogramming of the impulse generator. In both patients the electrode position was misplaced in a more ventral and anterior position and all 4 distal contacts reached upper part of the hippocampal formation. Both patients were cognitively intact. In a double blind pseudorandomised setting we stimulated the distal electrode using an inhibitory high frequency stimulation setting (120 Hz), an excitatory low frequency stimulation setting (20 Hz) or switched off the stimulation. A neuropsychological test battery was performed including test to assess memory, attention, working memory and executive functioning. A detailed neurological examination was part of the assessment. Results The neurological status did not differ in the different stimulation settings. In a 20 Hz stimulation setting both patients showed a clearly improvement in a word-pair retrieval task (memory) and in a digit ordering task (working memory) compared with the 120 Hz and the no-stimulation setting. The different stimulation settings did not affect attention and executive functions." @default.
- W2497248081 created "2016-08-23" @default.
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- W2497248081 date "2016-09-01" @default.
- W2497248081 modified "2023-09-27" @default.
- W2497248081 title "EP 19. Low frequency DBS of the hippocampal formation enhances memory function: Evidence from 2 case reports" @default.
- W2497248081 doi "https://doi.org/10.1016/j.clinph.2016.05.212" @default.
- W2497248081 hasPublicationYear "2016" @default.
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