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- W2497323729 abstract "Transdermal delivery system was the best alternative to oral dosage forms. Methotrexate was formulated in transdermal patches with different ratios of Ethyl cellulose and Hydroxy propyl methyl cellulose E15. Different chemical enhancers Tween 80, Span 80, Di methyl sulphoxide, and Isopro pyl myristate are used to enhance the drug delivery and its mechanism. The formulations were evaluated for In vitro release, Ex-vivo permeation studies. Further albino rats are used to study the skin irritation and pharmacokinetic parameters for optimized formulations. The mechanism of drug release follows the Higuchi kinetics and shows significance (p<0.01) with in the test formulations so, the drug release be both diffusion and erosion controlled rate release. DMSO shows prominent 7 fold increase of flux than the patches without enhancer. From the pharmacokinetic study it was observed that the bioavailability of patches significantly improved due to low elimination rate constant and high mean residence time of MTX (p<0.01)." @default.
- W2497323729 created "2016-08-23" @default.
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- W2497323729 date "2012-01-01" @default.
- W2497323729 modified "2023-09-28" @default.
- W2497323729 title "CHEMICAL PENETRATION ENHANCERS FOR ENHANCE TRANSDERMAL DELIVERY OF METHOTREXATE: FORMULATION, IN VITRO, EX VIVO AND IN VIVO CHARACTERIZATION" @default.
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