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- W2497333816 endingPage "835" @default.
- W2497333816 startingPage "793" @default.
- W2497333816 abstract "SUMMARY The c-Jun N-terminal kinases (JNKs), as members of the mitogen-activated protein kinase (MAPK) family, mediate eukaryotic cell responses to a wide range of abiotic and biotic stress insults. JNKs also regulate important physiological processes, including neuronal functions, immunological actions, and embryonic development, via their impact on gene expression, cytoskeletal protein dynamics, and cell death/survival pathways. Although the JNK pathway has been under study for >20 years, its complexity is still perplexing, with multiple protein partners of JNKs underlying the diversity of actions. Here we review the current knowledge of JNK structure and isoforms as well as the partnerships of JNKs with a range of intracellular proteins. Many of these proteins are direct substrates of the JNKs. We analyzed almost 100 of these target proteins in detail within a framework of their classification based on their regulation by JNKs. Examples of these JNK substrates include a diverse assortment of nuclear transcription factors (Jun, ATF2, Myc, Elk1), cytoplasmic proteins involved in cytoskeleton regulation (DCX, Tau, WDR62) or vesicular transport (JIP1, JIP3), cell membrane receptors (BMPR2), and mitochondrial proteins (Mcl1, Bim). In addition, because upstream signaling components impact JNK activity, we critically assessed the involvement of signaling scaffolds and the roles of feedback mechanisms in the JNK pathway. Despite a clarification of many regulatory events in JNK-dependent signaling during the past decade, many other structural and mechanistic insights are just beginning to be revealed. These advances open new opportunities to understand the role of JNK signaling in diverse physiological and pathophysiological states." @default.
- W2497333816 created "2016-08-23" @default.
- W2497333816 creator A5068951002 @default.
- W2497333816 creator A5081208395 @default.
- W2497333816 creator A5084648761 @default.
- W2497333816 creator A5091315271 @default.
- W2497333816 date "2016-09-01" @default.
- W2497333816 modified "2023-10-17" @default.
- W2497333816 title "JNK Signaling: Regulation and Functions Based on Complex Protein-Protein Partnerships" @default.
- W2497333816 cites W112316751 @default.
- W2497333816 cites W11476301 @default.
- W2497333816 cites W1483869935 @default.
- W2497333816 cites W1520408486 @default.
- W2497333816 cites W1528790659 @default.
- W2497333816 cites W1530284699 @default.
- W2497333816 cites W1531977757 @default.
- W2497333816 cites W1539871462 @default.
- W2497333816 cites W1543379203 @default.
- W2497333816 cites W1560650269 @default.
- W2497333816 cites W1572174728 @default.
- W2497333816 cites W1598771153 @default.
- W2497333816 cites W1600472471 @default.
- W2497333816 cites W1607410226 @default.
- W2497333816 cites W1779626885 @default.
- W2497333816 cites W1824702637 @default.
- W2497333816 cites W1833591189 @default.
- W2497333816 cites W1875580551 @default.
- W2497333816 cites W1893839706 @default.
- W2497333816 cites W1913648337 @default.
- W2497333816 cites W1963766715 @default.
- W2497333816 cites W1964199147 @default.
- W2497333816 cites W1965398768 @default.
- W2497333816 cites W1965490734 @default.
- W2497333816 cites W1966497951 @default.
- W2497333816 cites W1966655072 @default.
- W2497333816 cites W1966949462 @default.
- W2497333816 cites W1967068413 @default.
- W2497333816 cites W1967218150 @default.
- W2497333816 cites W1967667298 @default.
- W2497333816 cites W1967707945 @default.
- W2497333816 cites W1968382266 @default.
- W2497333816 cites W1968629260 @default.
- W2497333816 cites W1969176613 @default.
- W2497333816 cites W1969268163 @default.
- W2497333816 cites W1969719733 @default.
- W2497333816 cites W1969905987 @default.
- W2497333816 cites W1970446261 @default.
- W2497333816 cites W1970694501 @default.
- W2497333816 cites W1970958677 @default.
- W2497333816 cites W1971037507 @default.
- W2497333816 cites W1971523031 @default.
- W2497333816 cites W1971670935 @default.
- W2497333816 cites W1971708409 @default.
- W2497333816 cites W1971756681 @default.
- W2497333816 cites W1971955534 @default.
- W2497333816 cites W1972145919 @default.
- W2497333816 cites W1972169896 @default.
- W2497333816 cites W1972590376 @default.
- W2497333816 cites W1972628065 @default.
- W2497333816 cites W1972637719 @default.
- W2497333816 cites W1973363462 @default.
- W2497333816 cites W1973582015 @default.
- W2497333816 cites W1974268113 @default.
- W2497333816 cites W1974740818 @default.
- W2497333816 cites W1974889357 @default.
- W2497333816 cites W1974892121 @default.
- W2497333816 cites W1975215764 @default.
- W2497333816 cites W1976776826 @default.
- W2497333816 cites W1977052613 @default.
- W2497333816 cites W1977441346 @default.
- W2497333816 cites W1977672942 @default.
- W2497333816 cites W1977695981 @default.
- W2497333816 cites W1979514203 @default.
- W2497333816 cites W1980037943 @default.
- W2497333816 cites W1980376777 @default.
- W2497333816 cites W1980456750 @default.
- W2497333816 cites W1981071608 @default.
- W2497333816 cites W1981144703 @default.
- W2497333816 cites W1981209922 @default.
- W2497333816 cites W1982256662 @default.
- W2497333816 cites W1982284863 @default.
- W2497333816 cites W1982499214 @default.
- W2497333816 cites W1983506606 @default.
- W2497333816 cites W1983687466 @default.
- W2497333816 cites W1983893739 @default.
- W2497333816 cites W1984053927 @default.
- W2497333816 cites W1984110018 @default.
- W2497333816 cites W1984665850 @default.
- W2497333816 cites W1984903682 @default.
- W2497333816 cites W1985325808 @default.
- W2497333816 cites W1986051748 @default.
- W2497333816 cites W1987185222 @default.
- W2497333816 cites W1987821813 @default.
- W2497333816 cites W1988376074 @default.
- W2497333816 cites W1988741762 @default.
- W2497333816 cites W1988805210 @default.
- W2497333816 cites W1988865939 @default.
- W2497333816 cites W1988876415 @default.