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• W2497357110 abstract "Abstract Contemporary theories for the aetiology of borderline personality disorder (BPD) take a lifespan approach asserting that inborn biological predisposition is potentiated across development by environmental risk factors. In this review, we present and critically evaluate evidence on the neurobiology of BPD in childhood and adolescence, compare this evidence to the adult literature, and contextualise within a neurodevelopmental framework. A systematic review was conducted to identify studies examining the neurobiological (i.e. genetic, structural neuroimaging, neurophysiological, and neuropsychological) correlates of BPD symptoms in children and adolescents aged 19 years or under. We identified, quality assessed, and narratively summarised 34 studies published between 1980 and June 2016. Similar to findings in adult populations, twin studies indicated moderate to high levels of heritability of BPD, and there was some evidence for gene-environment interactions. Also consistent with adult reports is that some adolescents with BPD demonstrated structural (grey and white matter) alterations in frontolimbic regions and neuropsychological abnormalities (i.e. reduced executive function and disturbances in social cognition). These findings suggest that neurobiological abnormalities observed in adult BPD may not solely be the consequence of chronic morbidity or prolonged medication use. They also provide tentative support for neurodevelopmental theories of BPD by demonstrating that neurobiological markers may be observed from childhood onwards and interact with environmental factors to increase risk of BPD in young populations. Prospective studies with a range of repeated measures are now required to elucidate the temporal unfurling of neurobiological features and further delineate the complex pathways to BPD." @default.
• W2497357110 created "2016-08-23" @default.
• W2497357110 creator A5019840879 @default.
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• W2497357110 creator A5068318640 @default.
• W2497357110 creator A5078243761 @default.
• W2497357110 creator A5083053930 @default.
• W2497357110 date "2016-12-01" @default.
• W2497357110 modified "2023-10-16" @default.
• W2497357110 title "A systematic review of the neurobiological underpinnings of borderline personality disorder (BPD) in childhood and adolescence" @default.
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• W2497357110 doi "https://doi.org/10.1515/revneuro-2016-0026" @default.
• W2497357110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27518904" @default.
• W2497357110 hasPublicationYear "2016" @default.
• W2497357110 type Work @default.

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