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- W2497382541 endingPage "474" @default.
- W2497382541 startingPage "449" @default.
- W2497382541 abstract "The distinction originally made between innate and adaptive immunity has blurred. Innate immunity is an ensemble of cells and molecules that have evolved over time to perform a critical first responder’s function during the early stages of infection. Innate immunity holds the line, gathers information for ‘communication’ with more systemic elements of the adaptive immune system. Assessing the type of infection, first responders can call in effectors able to deal with the incursion. A major advance in understanding how changes in tissue status was recognized was the discovery of pattern recognition receptors (PRR) such as Toll-like receptors (TLR) that bind features of pathogens, as well as components of host cells that have died under duress. Barrier cells (keratinocytes, gut epithelia), along with WBC that are positioned beneath the barriers use a diverse set of PRR to recognize and differentiate different types of viruses, bacteria, fungi and parasites. PRR occupy different cellular compartments to ensure that they can monitor all possible locations that pathogens can replicate or exist in. The recognition is based on binding an integral part of the pathogen, a pattern: a consistently recognizable molecular signature of that type of pathogen. With the PRR strategy, if the pattern is there, then the pathogen is there and the battle is engaged." @default.
- W2497382541 created "2016-08-23" @default.
- W2497382541 creator A5091338129 @default.
- W2497382541 date "2015-01-01" @default.
- W2497382541 modified "2023-09-26" @default.
- W2497382541 title "Pattern Recognition Receptors and the Innate Immune Network" @default.
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