FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2497393003> ?p ?o ?g. }

• W2497393003 endingPage "1288" @default.
• W2497393003 startingPage "1273" @default.
• W2497393003 abstract "Bone marrow (BM) is a reservoir for immune and hematopoietic cells and critical for tissue repair and regeneration. All of these functions are severely altered in cirrhosis. We investigated the cellular and functional state of BM in cirrhosis patients. We studied the histological, cellular, and molecular changes in BM of cirrhosis patients (n = 168) and controls (n = 44). Hematopoietic stem cells (HSCs) and associated niche cells, mesenchymal stem cells, Schwann cells, neural fibers, and endothelial cells were evaluated by immunohistochemistry. Cytokines and growth factors were analyzed in peripheral blood and BM plasma. Cirrhotic BM showed an inverse correlation between cluster of differentiation 34+HSCs and Model of End‐Stage Liver Disease ( ρ = ‐0.582, P < 0.001) and Child's scores ( P < 0.038). BMs of cirrhosis patients with higher Model of End‐Stage Liver Disease (>15) showed significantly decreased HSCs, mesenchymal stem cells, Schwann cells, and neural fibers; increased interleukin‐1β ( P = 0.004), tumor necrosis factor‐α ( P = 0.040), and interferon‐γ ( P = 0.03); and decreased oncostatin M ( P = 0.04), stem cell factor ( P = 0.05), and stromal cell‐derived factor 1 ( P = 0.03) compared to those with lower Model of End‐Stage Liver Disease scores (≤15). The cluster of differentiation 34+ cell population was a predictor for the development of sepsis ( P < 0.001), and per unit loss increased the probability of sepsis by 16%. Cirrhosis patients with fewer HSCs had lower hemoglobin ( P = 0.05) and platelet counts ( P = 0.05) and showed early graft dysfunction. Conclusions: Increasing severity of cirrhosis causes derangement of the hematopoietic niche and loss of HSCs, contributing to the hematological and immunological dysfunctions and reduced potential for regeneration; restoring BM functions could provide new therapeutic options in cirrhosis. (H epatology 2016;64:1273‐1288)" @default.
• W2497393003 created "2016-08-23" @default.
• W2497393003 creator A5002245126 @default.
• W2497393003 creator A5004402988 @default.
• W2497393003 creator A5010639369 @default.
• W2497393003 creator A5013913860 @default.
• W2497393003 creator A5015911393 @default.
• W2497393003 creator A5020619179 @default.
• W2497393003 creator A5026415059 @default.
• W2497393003 creator A5030014538 @default.
• W2497393003 creator A5053632477 @default.
• W2497393003 creator A5054973352 @default.
• W2497393003 creator A5056571923 @default.
• W2497393003 creator A5059705306 @default.
• W2497393003 creator A5068701943 @default.
• W2497393003 creator A5088960523 @default.
• W2497393003 date "2016-08-24" @default.
• W2497393003 modified "2023-10-11" @default.
• W2497393003 title "Bone marrow stem cells and their niche components are adversely affected in advanced cirrhosis of the liver" @default.
• W2497393003 cites W1548421436 @default.
• W2497393003 cites W1719320996 @default.
• W2497393003 cites W1773130313 @default.
• W2497393003 cites W1832818975 @default.
• W2497393003 cites W1910694276 @default.
• W2497393003 cites W1980052833 @default.
• W2497393003 cites W1985534351 @default.
• W2497393003 cites W1988637814 @default.
• W2497393003 cites W1991950992 @default.
• W2497393003 cites W2009106222 @default.
• W2497393003 cites W2009519656 @default.
• W2497393003 cites W2025389760 @default.
• W2497393003 cites W2026443172 @default.
• W2497393003 cites W2028703250 @default.
• W2497393003 cites W2038920846 @default.
• W2497393003 cites W2043747739 @default.
• W2497393003 cites W2045032252 @default.
• W2497393003 cites W2052582241 @default.
• W2497393003 cites W2052730253 @default.
• W2497393003 cites W2070154483 @default.
• W2497393003 cites W2072411272 @default.
• W2497393003 cites W2078719918 @default.
• W2497393003 cites W2078886559 @default.
• W2497393003 cites W2080475565 @default.
• W2497393003 cites W2086969890 @default.
• W2497393003 cites W2087203965 @default.
• W2497393003 cites W2087990669 @default.
• W2497393003 cites W2090372962 @default.
• W2497393003 cites W2091600198 @default.
• W2497393003 cites W2100186921 @default.
• W2497393003 cites W2112254862 @default.
• W2497393003 cites W2114514472 @default.
• W2497393003 cites W2126338643 @default.
• W2497393003 cites W2131854245 @default.
• W2497393003 cites W2134267673 @default.
• W2497393003 cites W2136072463 @default.
• W2497393003 cites W2147822820 @default.
• W2497393003 cites W2154363126 @default.
• W2497393003 cites W2170201754 @default.
• W2497393003 cites W2171172082 @default.
• W2497393003 cites W2171869817 @default.
• W2497393003 cites W2339406441 @default.
• W2497393003 cites W272199479 @default.
• W2497393003 cites W4254771884 @default.
• W2497393003 doi "https://doi.org/10.1002/hep.28754" @default.
• W2497393003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27486864" @default.
• W2497393003 hasPublicationYear "2016" @default.
• W2497393003 type Work @default.
• W2497393003 sameAs 2497393003 @default.
• W2497393003 citedByCount "41" @default.
• W2497393003 countsByYear W24973930032017 @default.
• W2497393003 countsByYear W24973930032018 @default.
• W2497393003 countsByYear W24973930032019 @default.
• W2497393003 countsByYear W24973930032020 @default.
• W2497393003 countsByYear W24973930032021 @default.
• W2497393003 countsByYear W24973930032022 @default.
• W2497393003 countsByYear W24973930032023 @default.
• W2497393003 crossrefType "journal-article" @default.
• W2497393003 hasAuthorship W2497393003A5002245126 @default.
• W2497393003 hasAuthorship W2497393003A5004402988 @default.
• W2497393003 hasAuthorship W2497393003A5010639369 @default.
• W2497393003 hasAuthorship W2497393003A5013913860 @default.
• W2497393003 hasAuthorship W2497393003A5015911393 @default.
• W2497393003 hasAuthorship W2497393003A5020619179 @default.
• W2497393003 hasAuthorship W2497393003A5026415059 @default.
• W2497393003 hasAuthorship W2497393003A5030014538 @default.
• W2497393003 hasAuthorship W2497393003A5053632477 @default.
• W2497393003 hasAuthorship W2497393003A5054973352 @default.
• W2497393003 hasAuthorship W2497393003A5056571923 @default.
• W2497393003 hasAuthorship W2497393003A5059705306 @default.
• W2497393003 hasAuthorship W2497393003A5068701943 @default.
• W2497393003 hasAuthorship W2497393003A5088960523 @default.
• W2497393003 hasConcept C109159458 @default.
• W2497393003 hasConcept C126322002 @default.
• W2497393003 hasConcept C142724271 @default.
• W2497393003 hasConcept C16930146 @default.
• W2497393003 hasConcept C198826908 @default.
• W2497393003 hasConcept C203014093 @default.
• W2497393003 hasConcept C2777214474 @default.

• next