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- W2497399488 abstract "inhibit MIF biological activity. We report herein that the iminoqui- Fii none metabolite of acetaminophen, N-acetyl-p-benzoquinone imine fo (NAPQI), inhibits both the isomerase and the biological activities of pr MIF. The reaction between NAPQI and MIF is covalent and produces Na NAPQI-modified MIF species with diminished cell binding activity nc and decreased recognition by anti-MIF mAb. These data are consistent with a model by which the NAPQI reacts with the catalytic Pro-1 of MIF to disrupt the integrity of epitope(s) critical to MIF's biological activity h and point to the importance of the catalytic domain, but not the catalytic activity per se, in MIF function. These results also point to a powerful approach for the design of small molecule inhibitors of MIF based on interaction with its catalytic site and constitute an example of a pharmacophore capable of irreversibly inhibiting the action of a ta proinflammatory cytokine. L a(" @default.
- W2497399488 created "2016-08-23" @default.
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- W2497399488 date "2016-01-01" @default.
- W2497399488 modified "2023-09-24" @default.
- W2497399488 title "Inhibition of macrophage mi (MIF) tautomerase and biolo acetaminophen metabolites" @default.
- W2497399488 hasPublicationYear "2016" @default.
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