Matches in SemOpenAlex for { <https://semopenalex.org/work/W2497463669> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2497463669 abstract "Cisplatin (CDDP) resistance is the foremost obstacle in the treatment of ovarian cancer patients. According to the cancer stem cell hypothesis, the recurrence and chemoresistance are presumed to be linked to cancer stem/progenitor cells. Here, we investigated the cancer stem cell like phenotypes and mechanism of chemoresistance in CDDP resistant ovarian cancer cells. A well-established CDDP sensitive ovarian cancer cell line A2780 and its resistant clone A2780 Cp were used and we also developed a supra resistant clone (SKOV3 Cp) from a naturally CDDP resistant cell line SKOV3 by six shocks treatment. Sensitiveness to CDDP was evaluated by MTT assay and self renewal efficiency by sphere formation, noble agar and clonogenic assays. A few cancer hallmarks and stem-cell markers were characterized using flow cytometry. Molecular analysis was performed using quantitative PCR and western blotting. For the silencing of selected genes small interfering RNA (siRNA) based approaches was utilized. Both CDDP resistant A2780 Cp and supra resistant SKOV3 Cp cell lines showed significantly (P Taken together, present study showed for the first time that stemness gene ALDH1A1 can be involved in CDDP resistance via the upregulation of NEK-2 in ovarian or solid cancer. Citation Format: Md. Hafiz Uddin, Yong Sang Song. Association of ALDH1A1 with cisplatin resistance via modulation of NEK-2 in ovarian cancer stem-like cells. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 2511." @default.
- W2497463669 created "2016-08-23" @default.
- W2497463669 creator A5061398972 @default.
- W2497463669 creator A5081588594 @default.
- W2497463669 date "2016-07-15" @default.
- W2497463669 modified "2023-09-27" @default.
- W2497463669 title "Abstract 2511: Association of ALDH1A1 with cisplatin resistance via modulation of NEK-2 in ovarian cancer stem-like cells" @default.
- W2497463669 doi "https://doi.org/10.1158/1538-7445.am2016-2511" @default.
- W2497463669 hasPublicationYear "2016" @default.
- W2497463669 type Work @default.
- W2497463669 sameAs 2497463669 @default.
- W2497463669 citedByCount "0" @default.
- W2497463669 crossrefType "proceedings-article" @default.
- W2497463669 hasAuthorship W2497463669A5061398972 @default.
- W2497463669 hasAuthorship W2497463669A5081588594 @default.
- W2497463669 hasConcept C104317684 @default.
- W2497463669 hasConcept C117262875 @default.
- W2497463669 hasConcept C121608353 @default.
- W2497463669 hasConcept C136302470 @default.
- W2497463669 hasConcept C203014093 @default.
- W2497463669 hasConcept C2776694085 @default.
- W2497463669 hasConcept C2778239845 @default.
- W2497463669 hasConcept C2780427987 @default.
- W2497463669 hasConcept C28328180 @default.
- W2497463669 hasConcept C502942594 @default.
- W2497463669 hasConcept C54355233 @default.
- W2497463669 hasConcept C55427017 @default.
- W2497463669 hasConcept C81089528 @default.
- W2497463669 hasConcept C81885089 @default.
- W2497463669 hasConcept C86803240 @default.
- W2497463669 hasConcept C95444343 @default.
- W2497463669 hasConcept C96232424 @default.
- W2497463669 hasConceptScore W2497463669C104317684 @default.
- W2497463669 hasConceptScore W2497463669C117262875 @default.
- W2497463669 hasConceptScore W2497463669C121608353 @default.
- W2497463669 hasConceptScore W2497463669C136302470 @default.
- W2497463669 hasConceptScore W2497463669C203014093 @default.
- W2497463669 hasConceptScore W2497463669C2776694085 @default.
- W2497463669 hasConceptScore W2497463669C2778239845 @default.
- W2497463669 hasConceptScore W2497463669C2780427987 @default.
- W2497463669 hasConceptScore W2497463669C28328180 @default.
- W2497463669 hasConceptScore W2497463669C502942594 @default.
- W2497463669 hasConceptScore W2497463669C54355233 @default.
- W2497463669 hasConceptScore W2497463669C55427017 @default.
- W2497463669 hasConceptScore W2497463669C81089528 @default.
- W2497463669 hasConceptScore W2497463669C81885089 @default.
- W2497463669 hasConceptScore W2497463669C86803240 @default.
- W2497463669 hasConceptScore W2497463669C95444343 @default.
- W2497463669 hasConceptScore W2497463669C96232424 @default.
- W2497463669 hasLocation W24974636691 @default.
- W2497463669 hasOpenAccess W2497463669 @default.
- W2497463669 hasPrimaryLocation W24974636691 @default.
- W2497463669 hasRelatedWork W1889497323 @default.
- W2497463669 hasRelatedWork W2045194911 @default.
- W2497463669 hasRelatedWork W2073848139 @default.
- W2497463669 hasRelatedWork W2074786285 @default.
- W2497463669 hasRelatedWork W2171348590 @default.
- W2497463669 hasRelatedWork W2171909916 @default.
- W2497463669 hasRelatedWork W2319124915 @default.
- W2497463669 hasRelatedWork W2364612642 @default.
- W2497463669 hasRelatedWork W2429646895 @default.
- W2497463669 hasRelatedWork W2487987960 @default.
- W2497463669 hasRelatedWork W2497763899 @default.
- W2497463669 hasRelatedWork W2790044650 @default.
- W2497463669 hasRelatedWork W2795202975 @default.
- W2497463669 hasRelatedWork W2810377295 @default.
- W2497463669 hasRelatedWork W2883896179 @default.
- W2497463669 hasRelatedWork W2887954396 @default.
- W2497463669 hasRelatedWork W2971337387 @default.
- W2497463669 hasRelatedWork W3014900382 @default.
- W2497463669 hasRelatedWork W3046960580 @default.
- W2497463669 hasRelatedWork W3171262102 @default.
- W2497463669 isParatext "false" @default.
- W2497463669 isRetracted "false" @default.
- W2497463669 magId "2497463669" @default.
- W2497463669 workType "article" @default.