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• W2497486075 abstract "AIM: To review clinical practice for the initiation of home non-invasive ventilation (NIV) in children with neuromuscular disease (NMD) METHODS: Chart review of all children with NMD initiated on home NIV over a 16-year period (27 May 1995 - July 1 2011). Patients were divided intobaselineandrecentgroups to assess for changes in clinical practice. RESULTS: Forty-four patients were studied (mean age 12.7yrs, SD 4.8). NIV use increased over the study period (1.4 NIV initiations/yr inbaselinegroup vs. 4.9/yr inrecentgroup, p < 0.0001). Patients in thebaselinegroup had more advanced respiratory insufficiency (awake pCO2 58.3 vs. 46.3mmHg, (p= 0.016)). More patients in thebaselinegroup started NIV at the stage of diurnal hypercapnic respiratory failure (10 of 14 (71%) vs. 8 of 30 (27%), p = 0.008), while nocturnal hypoventilation with daytime normocapnia was the most common indication in therecentgroup (14 of 30 (47%) vs. 2 of 14 (14%), p= 0.049). Severe respiratory tract infections or atelectasis was the primary indication for NIV initiation for 6 of 30 (20%) in therecent � group compared with 0 of 14 (0%) inbaselinegroup. All children in thebaselinegroup had NIV initiated in the intensive care unit. In therecentgroup, 24 of 30 children (80%) were assessed as clinically stable and had NIV initiated on the respiratory ward without any major adverse events. The average length of hospital admission for NIV establishment was 6.9 days in the �baselinegroup and 3.5 days in therecentgroup (p = 0.004). CONCLUSIONS: NIV is increasingly being used to treat children with NMD, and it is being initiated at an earlier stage in the progression of respiratory insufficiency. For clinically stable children, NIV can be safely initiated on the ward avoiding intensive care admission." @default.
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• W2497486075 date "2014-04-11" @default.
• W2497486075 modified "2023-09-23" @default.
• W2497486075 title "Changing Patterns For The Introduction Of Non-Invasive Ventilation In Children With Neuromuscular Disease" @default.
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