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- W2497519361 abstract "This chapter reviews the well-characterized oncogenic events that result from translocations in leukemias and lymphomas, organized according to their effects in these fundamental regulatory processes during B lymphopoiesis. B-lineage leukemias and lymphomas are a heterogeneous group of malignancies that occur in the B-cell lymphoid compartment and have diverse cellular and histological features and different clinical characteristics. Among the most prominent mechanisms of B-cell oncogene activation are chromosomal rearrangements that place a proto-oncogene adjacent to an immunoglobulin ( Ig ) locus, resulting in the dysregulated expression of genes involved in the control of cellular proliferation, differentiation, or survival. A second mechanism of oncogene activation involves a chromosomal rearrangement that fuse the coding sequences of two different genes. These fusion genes encode chimeric oncoproteins that work as constitutively active tyrosine kinases or as novel transcription factors to activate oncogenic transcriptional programs. Thus, most oncogenic events that mediate the transformation of B lineage malignancies can be traced to a failure in one or more molecular pathways that control cell growth, differentiation, or survival during different s tages of B-cell development. The arrival of the BCR-ABL tyrosine kinase inhibitor STI571 on the clinical scene demonstrates the identification of the genes altered by chromosomal translocations, together with the analysis of their biochemical properties and their effects on cell proliferation and survival, has opened the field for the development of contemporary and highly specific anti-leukemia and anti-lymphoma drugs." @default.
- W2497519361 created "2016-08-23" @default.
- W2497519361 creator A5020549289 @default.
- W2497519361 creator A5085803011 @default.
- W2497519361 date "2004-01-01" @default.
- W2497519361 modified "2023-09-26" @default.
- W2497519361 title "Chromosomal Translocations in B-Cell Leukemias and Lymphomas" @default.
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