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- W2497532483 abstract "Closely related to the Iwao indole synthesis is the discovery by Hewson and colleagues, who found that ortho-sulfonamide ketene dithioacetal S-oxides readily cyclize to the corresponding 2-thiomethylindoles upon treatment with hydrochloric acid in the presence of hydrogen sulfide. The hydrogen sulfide prevents the formation of 3-chloroindoles, and the starting benzaldehydes were prepared from the appropriate methyl anthranilates by a sequence of reduction (LiAlH4) and oxidation (pyridinium chlorochromate)." @default.
- W2497532483 created "2016-08-23" @default.
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- W2497532483 date "2016-06-17" @default.
- W2497532483 modified "2023-09-23" @default.
- W2497532483 title "Hewson Indole Synthesis" @default.
- W2497532483 cites W2138318666 @default.
- W2497532483 doi "https://doi.org/10.1002/9781118695692.ch34" @default.
- W2497532483 hasPublicationYear "2016" @default.
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