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- W2497576210 abstract "Abstract The synthesis of organic compounds with the short-lived radioisotope fluorine-18 (T ½ = 110 m) is a new and exotic branch of organic chemistry. Fluorine itself is one of the most intractable elements of the periodic table, and special requirements added by the short half-life of the isotope and the tiny quantities of material involved provide additional constraints. The method of producing the radionuclide limits the range of reagents available, and the requirements of the chemical reaction be efficient in the utilization of fluorine requires the re-evaluation of many conventional procedures. In spite of these difficulties, a surprising variety of different compounds have been prepared, ranging from simple one carbon chloromethanes to sugars, fatty acids and multifunctionalize neurologically active drugs. A few of these compounds are now prepared routinely on a daily basis, and the number and variety can be expected to rise in the near future. This chapter reviews the state-of-the-art of synthetic organic chemistry with 18F." @default.
- W2497576210 created "2016-08-23" @default.
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- W2497576210 date "1982-01-01" @default.
- W2497576210 modified "2023-09-27" @default.
- W2497576210 title "ORGANIC SYNTHESIS INVOLVING FLUORINE-18" @default.
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