Matches in SemOpenAlex for { <https://semopenalex.org/work/W2497576887> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2497576887 endingPage "59" @default.
- W2497576887 startingPage "53" @default.
- W2497576887 abstract "There are data showing that exposition to PCNs mixture increased incidence of gastrointestinal and respiratory neoplasms, but data regarding incidence of hormone-dependent cancer so far not shown. The objective was to determine if exposure to single lower and higher chlorinated PCN congeners is associated with altered proliferation and apoptosis of estrogen dependent breast cancer cells, and whether such effects are related to induction of AhR and CYP1A1 protein expression. MCF-7 cells were exposed to PCN 34, 39, 42, 46, 48, 52, 53, 54, 66, 67, 70, 71, 73 and 74 at concentrations of 100-10,000pg/ml. We evaluated the action of these PCN congeners on cell proliferation, DNA fragmentation and caspase-8,-9 activity. AhR and CYP1A1 protein expression and CYP1A1 activity was evaluated at a concentration of 1000pg/ml. An opposite action of tri- to tetraCNs than of penta-to heptaCNs on cell proliferation and apoptosis was evident. Tetra PCNs increased cell proliferation, but had no effect on DNA fragmentation nor caspase activity. Fast induction of CYP1A1 protein expression under the influence of lower chlorinated PCNs suggests faster metabolism and a possible stimulatory action of locally formed metabolites on cell proliferation. None of the higher chlorinated PCNs affected cell proliferation but all higher chlorinated PCNs increased caspase-8 activity, and hexa PCNs also increased caspase-9 activity. The rapid activation of the Ah receptor and CYP1A1 protein expression by higher chlorinated PCNs point to their toxicity; however, it is not sufficient for potential carcinogenicity. Action of lower chlorinated naphthalenes metabolites should be explored." @default.
- W2497576887 created "2016-08-23" @default.
- W2497576887 creator A5056988673 @default.
- W2497576887 creator A5060375916 @default.
- W2497576887 creator A5069220435 @default.
- W2497576887 date "2016-07-01" @default.
- W2497576887 modified "2023-10-18" @default.
- W2497576887 title "Differences in the action of lower and higher chlorinated polychlorinated naphthalene (PCN) congeners on estrogen dependent breast cancer cell line viability and apoptosis, and its correlation with Ahr and CYP1A1 expression." @default.
- W2497576887 cites W1962747648 @default.
- W2497576887 cites W1974546331 @default.
- W2497576887 cites W1977017738 @default.
- W2497576887 cites W1981143370 @default.
- W2497576887 cites W1995252519 @default.
- W2497576887 cites W2002684102 @default.
- W2497576887 cites W2009330673 @default.
- W2497576887 cites W2012714282 @default.
- W2497576887 cites W2023348377 @default.
- W2497576887 cites W2025902090 @default.
- W2497576887 cites W2027631121 @default.
- W2497576887 cites W2030607204 @default.
- W2497576887 cites W2032958713 @default.
- W2497576887 cites W2043077027 @default.
- W2497576887 cites W2045931107 @default.
- W2497576887 cites W2050131392 @default.
- W2497576887 cites W2057743666 @default.
- W2497576887 cites W2060409301 @default.
- W2497576887 cites W2067660012 @default.
- W2497576887 cites W2069618813 @default.
- W2497576887 cites W2070189353 @default.
- W2497576887 cites W2071079019 @default.
- W2497576887 cites W2103562476 @default.
- W2497576887 cites W2109830579 @default.
- W2497576887 doi "https://doi.org/10.1016/j.tox.2016.08.004" @default.
- W2497576887 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27501765" @default.
- W2497576887 hasPublicationYear "2016" @default.
- W2497576887 type Work @default.
- W2497576887 sameAs 2497576887 @default.
- W2497576887 citedByCount "11" @default.
- W2497576887 countsByYear W24975768872017 @default.
- W2497576887 countsByYear W24975768872018 @default.
- W2497576887 countsByYear W24975768872019 @default.
- W2497576887 countsByYear W24975768872020 @default.
- W2497576887 countsByYear W24975768872021 @default.
- W2497576887 countsByYear W24975768872022 @default.
- W2497576887 countsByYear W24975768872023 @default.
- W2497576887 crossrefType "journal-article" @default.
- W2497576887 hasAuthorship W2497576887A5056988673 @default.
- W2497576887 hasAuthorship W2497576887A5060375916 @default.
- W2497576887 hasAuthorship W2497576887A5069220435 @default.
- W2497576887 hasConcept C114246631 @default.
- W2497576887 hasConcept C12519072 @default.
- W2497576887 hasConcept C185592680 @default.
- W2497576887 hasConcept C190283241 @default.
- W2497576887 hasConcept C31573885 @default.
- W2497576887 hasConcept C43759708 @default.
- W2497576887 hasConcept C502942594 @default.
- W2497576887 hasConcept C55493867 @default.
- W2497576887 hasConcept C62112901 @default.
- W2497576887 hasConcept C86803240 @default.
- W2497576887 hasConceptScore W2497576887C114246631 @default.
- W2497576887 hasConceptScore W2497576887C12519072 @default.
- W2497576887 hasConceptScore W2497576887C185592680 @default.
- W2497576887 hasConceptScore W2497576887C190283241 @default.
- W2497576887 hasConceptScore W2497576887C31573885 @default.
- W2497576887 hasConceptScore W2497576887C43759708 @default.
- W2497576887 hasConceptScore W2497576887C502942594 @default.
- W2497576887 hasConceptScore W2497576887C55493867 @default.
- W2497576887 hasConceptScore W2497576887C62112901 @default.
- W2497576887 hasConceptScore W2497576887C86803240 @default.
- W2497576887 hasLocation W24975768871 @default.
- W2497576887 hasLocation W24975768872 @default.
- W2497576887 hasOpenAccess W2497576887 @default.
- W2497576887 hasPrimaryLocation W24975768871 @default.
- W2497576887 hasRelatedWork W1907109094 @default.
- W2497576887 hasRelatedWork W1981477304 @default.
- W2497576887 hasRelatedWork W2008479527 @default.
- W2497576887 hasRelatedWork W2063728947 @default.
- W2497576887 hasRelatedWork W2073966313 @default.
- W2497576887 hasRelatedWork W2117519097 @default.
- W2497576887 hasRelatedWork W2161791039 @default.
- W2497576887 hasRelatedWork W2186559937 @default.
- W2497576887 hasRelatedWork W2401479182 @default.
- W2497576887 hasRelatedWork W2461664441 @default.
- W2497576887 hasVolume "366-367" @default.
- W2497576887 isParatext "false" @default.
- W2497576887 isRetracted "false" @default.
- W2497576887 magId "2497576887" @default.
- W2497576887 workType "article" @default.