FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W249761738> ?p ?o ?g. }

• W249761738 endingPage "8" @default.
• W249761738 startingPage "373" @default.
• W249761738 abstract "Triggering of the T-cell receptor by anti-CD3 monoclonal antibodies (mAb), for example OKT3, induces accessory cell (AC)-dependent interleukin-2 (IL-2) and IL-2 receptor synthesis, and ultimately, T-cell proliferation. We report on the ability of a HLA-class I specific monomorphic mAb, namely FMC16, to inhibit OKT3-driven T-cell mitogenesis. FMC16 was apparently selective for OKT3 because it did not block Concanavalin A (Con A) or mAb Leu-4 induced proliferation. Moreover, this effect was not due to non-specific toxicity nor interference with OKT3 binding. Kinetic analysis showed that FMC16 was inhibitory when added up to 24 hr after initiation of culture. FMC16 drastically reduced both IL-2 production and IL-2 receptor expression, but did not interfere with IL-2 responsiveness. The inhibitory effects were not altered by the addition of exogenous IL-2 if FMC16 was present at the beginning of culture; however, IL-2 did restore proliferation if FMC16 was not added until 3 to 6 hr after initiation of culture. This coincided exactly with an IL-2 mediated increase in the level of TAC-positive cells. Furthermore, T-cell activation triggered by the synergistic action of OKT3 and a phorbol ester (TPA) in the absence of AC was also blocked by FMC16, suggesting that inhibition was not AC-dependent. Taken together, these results indicate that FMC16 interferes with early signals leading to IL-2 production and IL-2 receptor expression and suggest that HLA-class I determinants play an early role in T-cell activation." @default.
• W249761738 created "2016-06-24" @default.
• W249761738 creator A5005615706 @default.
• W249761738 creator A5018850788 @default.
• W249761738 creator A5057402859 @default.
• W249761738 date "1988-11-01" @default.
• W249761738 modified "2023-10-18" @default.
• W249761738 title "Specific inhibition of OKT3-driven T-cell mitogenesis by an anti HLA-class I monoclonal antibody." @default.
• W249761738 cites W1506157243 @default.
• W249761738 cites W1506397040 @default.
• W249761738 cites W1546326396 @default.
• W249761738 cites W1605010559 @default.
• W249761738 cites W1837437390 @default.
• W249761738 cites W1885675676 @default.
• W249761738 cites W1928575782 @default.
• W249761738 cites W1969851519 @default.
• W249761738 cites W1972828428 @default.
• W249761738 cites W1977864623 @default.
• W249761738 cites W1987440121 @default.
• W249761738 cites W1988448631 @default.
• W249761738 cites W1998206923 @default.
• W249761738 cites W2002377882 @default.
• W249761738 cites W2004382063 @default.
• W249761738 cites W2030620033 @default.
• W249761738 cites W2049704246 @default.
• W249761738 cites W2056418190 @default.
• W249761738 cites W2070616677 @default.
• W249761738 cites W2082422886 @default.
• W249761738 cites W2115044816 @default.
• W249761738 cites W2115409850 @default.
• W249761738 cites W2145724606 @default.
• W249761738 cites W2148231718 @default.
• W249761738 cites W2161798777 @default.
• W249761738 cites W2165349231 @default.
• W249761738 cites W2170924043 @default.
• W249761738 cites W40843633 @default.
• W249761738 cites W4206163632 @default.
• W249761738 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1385474" @default.
• W249761738 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3264808" @default.
• W249761738 hasPublicationYear "1988" @default.
• W249761738 type Work @default.
• W249761738 sameAs 249761738 @default.
• W249761738 citedByCount "1" @default.
• W249761738 crossrefType "journal-article" @default.
• W249761738 hasAuthorship W249761738A5005615706 @default.
• W249761738 hasAuthorship W249761738A5018850788 @default.
• W249761738 hasAuthorship W249761738A5057402859 @default.
• W249761738 hasConcept C147483822 @default.
• W249761738 hasConcept C153911025 @default.
• W249761738 hasConcept C159654299 @default.
• W249761738 hasConcept C170493617 @default.
• W249761738 hasConcept C19869320 @default.
• W249761738 hasConcept C202751555 @default.
• W249761738 hasConcept C203014093 @default.
• W249761738 hasConcept C2776090121 @default.
• W249761738 hasConcept C2777371288 @default.
• W249761738 hasConcept C2992881475 @default.
• W249761738 hasConcept C2993002077 @default.
• W249761738 hasConcept C49382859 @default.
• W249761738 hasConcept C542903549 @default.
• W249761738 hasConcept C54355233 @default.
• W249761738 hasConcept C55493867 @default.
• W249761738 hasConcept C62112901 @default.
• W249761738 hasConcept C81885089 @default.
• W249761738 hasConcept C86803240 @default.
• W249761738 hasConcept C8891405 @default.
• W249761738 hasConcept C95444343 @default.
• W249761738 hasConceptScore W249761738C147483822 @default.
• W249761738 hasConceptScore W249761738C153911025 @default.
• W249761738 hasConceptScore W249761738C159654299 @default.
• W249761738 hasConceptScore W249761738C170493617 @default.
• W249761738 hasConceptScore W249761738C19869320 @default.
• W249761738 hasConceptScore W249761738C202751555 @default.
• W249761738 hasConceptScore W249761738C203014093 @default.
• W249761738 hasConceptScore W249761738C2776090121 @default.
• W249761738 hasConceptScore W249761738C2777371288 @default.
• W249761738 hasConceptScore W249761738C2992881475 @default.
• W249761738 hasConceptScore W249761738C2993002077 @default.
• W249761738 hasConceptScore W249761738C49382859 @default.
• W249761738 hasConceptScore W249761738C542903549 @default.
• W249761738 hasConceptScore W249761738C54355233 @default.
• W249761738 hasConceptScore W249761738C55493867 @default.
• W249761738 hasConceptScore W249761738C62112901 @default.
• W249761738 hasConceptScore W249761738C81885089 @default.
• W249761738 hasConceptScore W249761738C86803240 @default.
• W249761738 hasConceptScore W249761738C8891405 @default.
• W249761738 hasConceptScore W249761738C95444343 @default.
• W249761738 hasIssue "3" @default.
• W249761738 hasLocation W2497617381 @default.
• W249761738 hasOpenAccess W249761738 @default.
• W249761738 hasPrimaryLocation W2497617381 @default.
• W249761738 hasRelatedWork W1548380108 @default.
• W249761738 hasRelatedWork W1554952666 @default.
• W249761738 hasRelatedWork W1689731491 @default.
• W249761738 hasRelatedWork W1985689958 @default.
• W249761738 hasRelatedWork W2065367149 @default.
• W249761738 hasRelatedWork W2122756653 @default.
• W249761738 hasRelatedWork W2131198722 @default.

• next