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- W2497966757 abstract "A comprehensive screening battery of neurobehavioral tests, applicable to combustion toxicology research, is being developed at the Naval Medical Research Institute Toxicology Detachment (NMRI/TD) of the Tri-Service Toxicology Consortium at Wright-Patterson AFB, OH. This screening battery, evaluating small animal responses, will be used to predict human neurobehavioral effects of non-lethal toxic exposures in a diversity of real world operational scenarios. While the scientific literature contains over 100,000 studies addressing effects of toxic substances on lethality or single behavioral endpoints, few have used an integrated test battery to predict toxicity effects in real world scenarios. Many jobs, occupations and human functions require attention and judgment, performance of precise actions in a specified sequence, fine motor control and integrated motivation. Regardless of the scenario, the critical factor in risk assessment is the capability for prediction of the individual's ability to make decisions and execute precise behaviors that will enable mission completion. TheNMRI/TD test battery is designed to evaluate the impact of individual toxicants or the interaction of combined toxicants within a complex mixture on a specific operational performance. Current applications of the battery model human behavioral and performance deficits associated with acute exposure to fire gases, fire extinguishants and extinguishant byproducts. Validation of the battery involves comparisons of documented human deficits associated with exposure to acceptable levels of known toxicants or pharmaceutical drugs with animal responses to comparable levels of the same compounds." @default.
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- W2497966757 date "1995-07-21" @default.
- W2497966757 modified "2023-10-09" @default.
- W2497966757 title "Application of the Naval Medical Research Institute Toxicology Detachment Neurobehavioral Screening Battery to Combustion Toxicology" @default.
- W2497966757 doi "https://doi.org/10.1021/bk-1995-0599.ch023" @default.
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