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- W249821462 abstract "The macrophage colony-stimulating factors (CSF-1) belong to a group of proteins that regulate the production of blood cells (1). CSF-1 is a specific growth and differentiation factor for bone marrow progenitor cells of the mononuclear phagocyte lineage and also promotes the proliferation of mature macrophages via specific receptors on the responding cells (2,3). CSF-1 also has a variety of stimulatory effects on the function of macrophages and monocytes. Human CSF-1 is fully active on murine cells; murine CSF-1 is not reported to be active on human cells. Human (4,5) and murine cDNA’s (6) for CSF-1 have been cloned and the human genome sequenced (5). The genetic and protein forms of CSF-1 are considerably more complex than of the other hemopoietic growth factors so far studied. In this paper, we summarize the structural features of the CSF-1 gene, the various mRNA molecules, polypeptide precursor and processed, mature hormone. The promotion of macrophage tumoricidal capacity by CSF-1 and the activity of recombinant and conventional CSF-1 proteins in stimulating human bone marrow colony formation is also described." @default.
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- W249821462 date "1987-01-01" @default.
- W249821462 modified "2023-09-27" @default.
- W249821462 title "The Molecular and Biological Properties of the Human and Murine Members of the CSF-1 Family" @default.
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- W249821462 doi "https://doi.org/10.1007/978-1-4612-4598-8_27" @default.
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