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- W2498279506 abstract "Objective: The objective of this study was to synthesize 2,3,4,9-tetrahydro-1H-carbazole derivatives and evaluation of their anticancer activity by MTT assay. Methods: We have synthesized a series of novel 2,3,4,9-tetrahydro-1H-carbazole derivatives of 1-4(substituted phenyl)-3-1-9 (2,3,4,9-tetrahydro1H-carbazole-9yl)-propane-1-one, by Indolization of 2 ml (0.1 mol) cyclohexanone and 2 ml (0.1 mol) phenyl hydrazine in the presence of a few drops of glacial acetic acid. The mixture was placed in a microwave for 5 min. to give 2, 3, 4, 9-tetrahydro-1H-carbazole (J). Then titled compounds were prepared by Mannich reaction in which compound (J) condensed with formaldehyde and various aromatic acetophenone (J-1 to J-5). Finally, all synthesized products were characterized on the basis of melting point, R f" @default.
- W2498279506 created "2016-08-23" @default.
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- W2498279506 date "2016-01-01" @default.
- W2498279506 modified "2023-09-24" @default.
- W2498279506 title "ANTICANCER ACTIVITY OF MICROWAVE ASSISTED NEWLY SYNTHESIZED 2,3,4,9- TETRAHYDRO-1H-CARBAZOLE DERIVATIVES Short Communication" @default.
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