Matches in SemOpenAlex for { <https://semopenalex.org/work/W2498292861> ?p ?o ?g. }
- W2498292861 abstract "We examined the effects of the Rho-associated protein kinase (ROCK) inhibitor Y-27632 on voltage-dependent K+ (Kv) channels in rabbit coronary arterial smooth muscle cells using the whole-cell patch clamp technique. Y-27632 reduced the amplitude of the Kv current in a concentration-dependent manner, with an IC50 of 0.87 ± 0.06 μmol/l and a Hill coefficient of 1.48 ± 0.06. Y-27632 did not affect the steady-state activation or inactivation curves, suggesting that the drug does not affect the voltage sensitivity of Kv channels. Another ROCK inhibitor, H-1152, did not affect the Kv current and had no significant effect on the Y-27632-induced inhibition of Kv channels, indicating that the inhibitory effect of Y-27632 on the Kv current is independent of ROCK signaling. From these results, we conclude that Y-27632 inhibits the Kv channel current in a dose-dependent and ROCK signaling-independent manner." @default.
- W2498292861 created "2016-08-23" @default.
- W2498292861 creator A5002918933 @default.
- W2498292861 creator A5007456792 @default.
- W2498292861 creator A5032388208 @default.
- W2498292861 creator A5033042170 @default.
- W2498292861 creator A5054192049 @default.
- W2498292861 creator A5057841119 @default.
- W2498292861 creator A5058101079 @default.
- W2498292861 creator A5069292897 @default.
- W2498292861 creator A5070314327 @default.
- W2498292861 creator A5072401668 @default.
- W2498292861 creator A5077165659 @default.
- W2498292861 creator A5083695658 @default.
- W2498292861 creator A5091654903 @default.
- W2498292861 date "2016-01-01" @default.
- W2498292861 modified "2023-09-24" @default.
- W2498292861 title "Y-27632, a Rho-Associated Protein Kinase Inhibitor, Inhibits Voltage-Dependent K+ Channels in Rabbit Coronary Arterial Smooth Muscle Cells" @default.
- W2498292861 cites W1594278877 @default.
- W2498292861 cites W1753089048 @default.
- W2498292861 cites W1913443320 @default.
- W2498292861 cites W1968661531 @default.
- W2498292861 cites W1968881929 @default.
- W2498292861 cites W1969459966 @default.
- W2498292861 cites W1973866585 @default.
- W2498292861 cites W1984443415 @default.
- W2498292861 cites W1993268216 @default.
- W2498292861 cites W1994468708 @default.
- W2498292861 cites W2000911544 @default.
- W2498292861 cites W2002226554 @default.
- W2498292861 cites W2002409177 @default.
- W2498292861 cites W2002838213 @default.
- W2498292861 cites W2008029604 @default.
- W2498292861 cites W2012230028 @default.
- W2498292861 cites W2014609720 @default.
- W2498292861 cites W2031969987 @default.
- W2498292861 cites W2034146129 @default.
- W2498292861 cites W2036625562 @default.
- W2498292861 cites W2044149389 @default.
- W2498292861 cites W2052074844 @default.
- W2498292861 cites W2059384448 @default.
- W2498292861 cites W2060974177 @default.
- W2498292861 cites W2062865173 @default.
- W2498292861 cites W2064574428 @default.
- W2498292861 cites W2071388820 @default.
- W2498292861 cites W2071818983 @default.
- W2498292861 cites W2073251400 @default.
- W2498292861 cites W2075811835 @default.
- W2498292861 cites W2093472481 @default.
- W2498292861 cites W2095734666 @default.
- W2498292861 cites W2096153581 @default.
- W2498292861 cites W2096791952 @default.
- W2498292861 cites W2099309899 @default.
- W2498292861 cites W2114940281 @default.
- W2498292861 cites W2149782869 @default.
- W2498292861 cites W2156103849 @default.
- W2498292861 cites W2174276283 @default.
- W2498292861 cites W2266973650 @default.
- W2498292861 cites W2395707267 @default.
- W2498292861 doi "https://doi.org/10.1159/000447745" @default.
- W2498292861 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27438463" @default.
- W2498292861 hasPublicationYear "2016" @default.
- W2498292861 type Work @default.
- W2498292861 sameAs 2498292861 @default.
- W2498292861 citedByCount "6" @default.
- W2498292861 countsByYear W24982928612016 @default.
- W2498292861 countsByYear W24982928612017 @default.
- W2498292861 countsByYear W24982928612019 @default.
- W2498292861 countsByYear W24982928612020 @default.
- W2498292861 crossrefType "journal-article" @default.
- W2498292861 hasAuthorship W2498292861A5002918933 @default.
- W2498292861 hasAuthorship W2498292861A5007456792 @default.
- W2498292861 hasAuthorship W2498292861A5032388208 @default.
- W2498292861 hasAuthorship W2498292861A5033042170 @default.
- W2498292861 hasAuthorship W2498292861A5054192049 @default.
- W2498292861 hasAuthorship W2498292861A5057841119 @default.
- W2498292861 hasAuthorship W2498292861A5058101079 @default.
- W2498292861 hasAuthorship W2498292861A5069292897 @default.
- W2498292861 hasAuthorship W2498292861A5070314327 @default.
- W2498292861 hasAuthorship W2498292861A5072401668 @default.
- W2498292861 hasAuthorship W2498292861A5077165659 @default.
- W2498292861 hasAuthorship W2498292861A5083695658 @default.
- W2498292861 hasAuthorship W2498292861A5091654903 @default.
- W2498292861 hasConcept C100837961 @default.
- W2498292861 hasConcept C12554922 @default.
- W2498292861 hasConcept C126322002 @default.
- W2498292861 hasConcept C134018914 @default.
- W2498292861 hasConcept C147944092 @default.
- W2498292861 hasConcept C17077164 @default.
- W2498292861 hasConcept C184235292 @default.
- W2498292861 hasConcept C185263204 @default.
- W2498292861 hasConcept C185592680 @default.
- W2498292861 hasConcept C201800478 @default.
- W2498292861 hasConcept C202751555 @default.
- W2498292861 hasConcept C2777752497 @default.
- W2498292861 hasConcept C2992686903 @default.
- W2498292861 hasConcept C55493867 @default.
- W2498292861 hasConcept C71924100 @default.
- W2498292861 hasConcept C86803240 @default.
- W2498292861 hasConceptScore W2498292861C100837961 @default.