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- W2498492890 endingPage "94" @default.
- W2498492890 startingPage "83" @default.
- W2498492890 abstract "Twenty years have passed since the dysconnection hypothesis was first proposed (Friston and Frith, 1995; Weinberger, 1993). In that time, neuroscience has witnessed tremendous advances: we now live in a world of non-invasive neuroanatomy, computational neuroimaging and the Bayesian brain. The genomics era has come and gone. Connectomics and large-scale neuroinformatics initiatives are emerging everywhere. So where is the dysconnection hypothesis now? This article considers how the notion of schizophrenia as a dysconnection syndrome has developed – and how it has been enriched by recent advances in clinical neuroscience. In particular, we examine the dysconnection hypothesis in the context of (i) theoretical neurobiology and computational psychiatry; (ii) the empirical insights afforded by neuroimaging and associated connectomics – and (iii) how bottom-up (molecular biology and genetics) and top-down (systems biology) perspectives are converging on the mechanisms and nature of dysconnections in schizophrenia." @default.
- W2498492890 created "2016-08-23" @default.
- W2498492890 creator A5016719332 @default.
- W2498492890 creator A5046379780 @default.
- W2498492890 creator A5083410594 @default.
- W2498492890 creator A5086852785 @default.
- W2498492890 date "2016-10-01" @default.
- W2498492890 modified "2023-10-15" @default.
- W2498492890 title "The dysconnection hypothesis (2016)" @default.
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