FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2498518540> ?p ?o ?g. }

• W2498518540 endingPage "492" @default.
• W2498518540 startingPage "480" @default.
• W2498518540 abstract "Endogenous interferon beta (IFNβ) is an important cytokine involved in several chronic inflammatory diseases, such as Multiple Sclerosis (MS). In spite of the numerous therapeutic approaches available for MS patients, the administration of recombinant IFNβ continues being one of the first line treatment to these patients. The soluble form of IFNβ receptor (sIFNAR2) could act as critical regulator of the endogenous and the systemically administered IFNβ, but whether it functions as an agonist or antagonist of its ligand is not completely elucidated. Morover, the possible role of sIFNAR2 in autoimmune diseases like MS is still unknown and so far overlooked. Here we evaluated the efficacy of the combined therapy of IFNβ and our recombinant protein analogous to human sIFNAR2 as a treatment in a chronic mice model of MS (CP-EAE). We also tested the effect of the sIFNAR2 administered as a monotherapy over these EAE-animals. The results showed that our recombinant sIFNAR2 protein potentiates the immunomodulatory effects of exogenous IFNβ in CP-EAE by increasing the reduction of the induced inflammation and the tissue damage. Furthermore, we demonstrate for the first time that sIFNAR2 shows intrinsic properties by modulating the CP-EAE progression and the neuroinflammation processes related to this disease. Another intrinsic activity showed by sIFNAR2 is the inhibition of the T cells proliferation, which increase its potential as therapeutic molecule." @default.
• W2498518540 created "2016-08-23" @default.
• W2498518540 creator A5011370161 @default.
• W2498518540 creator A5016014851 @default.
• W2498518540 creator A5024270924 @default.
• W2498518540 creator A5035645353 @default.
• W2498518540 creator A5043192785 @default.
• W2498518540 creator A5049451965 @default.
• W2498518540 creator A5057965399 @default.
• W2498518540 creator A5059379547 @default.
• W2498518540 creator A5073322570 @default.
• W2498518540 creator A5083420943 @default.
• W2498518540 creator A5084286540 @default.
• W2498518540 date "2016-11-01" @default.
• W2498518540 modified "2023-10-10" @default.
• W2498518540 title "Recombinant soluble IFN receptor (sIFNAR2) exhibits intrinsic therapeutic efficacy in a murine model of Multiple Sclerosis" @default.
• W2498518540 cites W1498232149 @default.
• W2498518540 cites W1515592753 @default.
• W2498518540 cites W1534418440 @default.
• W2498518540 cites W1776476655 @default.
• W2498518540 cites W1825094415 @default.
• W2498518540 cites W1896921323 @default.
• W2498518540 cites W1931342651 @default.
• W2498518540 cites W1955666311 @default.
• W2498518540 cites W1974997700 @default.
• W2498518540 cites W1988567136 @default.
• W2498518540 cites W1991174168 @default.
• W2498518540 cites W2006061341 @default.
• W2498518540 cites W2007139863 @default.
• W2498518540 cites W2007360114 @default.
• W2498518540 cites W2010060227 @default.
• W2498518540 cites W2012265042 @default.
• W2498518540 cites W2013582179 @default.
• W2498518540 cites W2026951449 @default.
• W2498518540 cites W2038079382 @default.
• W2498518540 cites W2050613383 @default.
• W2498518540 cites W2057721119 @default.
• W2498518540 cites W2059653753 @default.
• W2498518540 cites W2062159906 @default.
• W2498518540 cites W2068103783 @default.
• W2498518540 cites W2075527727 @default.
• W2498518540 cites W2076988113 @default.
• W2498518540 cites W2078844752 @default.
• W2498518540 cites W2081202846 @default.
• W2498518540 cites W2088133130 @default.
• W2498518540 cites W2089003208 @default.
• W2498518540 cites W2097822295 @default.
• W2498518540 cites W2098143064 @default.
• W2498518540 cites W2100942578 @default.
• W2498518540 cites W2106090998 @default.
• W2498518540 cites W2107277218 @default.
• W2498518540 cites W2109092008 @default.
• W2498518540 cites W2120406095 @default.
• W2498518540 cites W2124943069 @default.
• W2498518540 cites W2131900850 @default.
• W2498518540 cites W2140830894 @default.
• W2498518540 cites W2175891434 @default.
• W2498518540 cites W4294216491 @default.
• W2498518540 cites W823098362 @default.
• W2498518540 doi "https://doi.org/10.1016/j.neuropharm.2016.07.026" @default.
• W2498518540 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27452720" @default.
• W2498518540 hasPublicationYear "2016" @default.
• W2498518540 type Work @default.
• W2498518540 sameAs 2498518540 @default.
• W2498518540 citedByCount "5" @default.
• W2498518540 countsByYear W24985185402018 @default.
• W2498518540 countsByYear W24985185402019 @default.
• W2498518540 countsByYear W24985185402020 @default.
• W2498518540 countsByYear W24985185402021 @default.
• W2498518540 crossrefType "journal-article" @default.
• W2498518540 hasAuthorship W2498518540A5011370161 @default.
• W2498518540 hasAuthorship W2498518540A5016014851 @default.
• W2498518540 hasAuthorship W2498518540A5024270924 @default.
• W2498518540 hasAuthorship W2498518540A5035645353 @default.
• W2498518540 hasAuthorship W2498518540A5043192785 @default.
• W2498518540 hasAuthorship W2498518540A5049451965 @default.
• W2498518540 hasAuthorship W2498518540A5057965399 @default.
• W2498518540 hasAuthorship W2498518540A5059379547 @default.
• W2498518540 hasAuthorship W2498518540A5073322570 @default.
• W2498518540 hasAuthorship W2498518540A5083420943 @default.
• W2498518540 hasAuthorship W2498518540A5084286540 @default.
• W2498518540 hasConcept C104317684 @default.
• W2498518540 hasConcept C126322002 @default.
• W2498518540 hasConcept C16613235 @default.
• W2498518540 hasConcept C170493617 @default.
• W2498518540 hasConcept C185592680 @default.
• W2498518540 hasConcept C203014093 @default.
• W2498518540 hasConcept C2776178377 @default.
• W2498518540 hasConcept C2776914184 @default.
• W2498518540 hasConcept C2778690821 @default.
• W2498518540 hasConcept C2778938600 @default.
• W2498518540 hasConcept C2780640218 @default.
• W2498518540 hasConcept C40767141 @default.
• W2498518540 hasConcept C55493867 @default.
• W2498518540 hasConcept C6929976 @default.
• W2498518540 hasConcept C71924100 @default.
• W2498518540 hasConcept C87753298 @default.
• W2498518540 hasConcept C98274493 @default.

• next