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• W2498528043 abstract ".The inner wall of all blood vessels is lined by a monolayer of endothelial cells creating a natural barrier and dynamic interface between the blood and underlying vascular smooth muscle cells. The enzyme endothelial nitric oxide synthase (eNOS) is expressed in endothelial cells. It produces nitric oxide (NO), which is an important signaling molecule in the cardiovascular system: NO exerts a direct vasodilatory effect on blood vessels, inhibits the proliferation of vascular smooth muscle cells, attenuates the adhesion of inflammatory cells to the endothelium, and inhibits platelet aggregation. Therefore, NO is considered a major anti-atherogenic factor in the vasculature. Reduced eNOS activity and subsequently decreased NO bioavailability in blood vessels is associated with the development of atherosclerosis. Since the endothelium constitutes the predominant tissue to which any given molecule is exposed after absorption into the bloodstream, it is a potential site of action for compounds taken up with the daily diet. Several plant-derived nutrients and their metabolites have been demonstrated to increase eNOS activity, such as red wine polyphenols, isoflavones from soybeans, compounds from green tea, ginseng, or pomegranate juice." @default.
• W2498528043 created "2016-08-23" @default.
• W2498528043 creator A5029839891 @default.
• W2498528043 creator A5084218913 @default.
• W2498528043 date "2010-01-01" @default.
• W2498528043 modified "2023-09-23" @default.
• W2498528043 title "Nitric Oxide Synthase and Olive Oil Hydroxytyrosol in Endothelial Cells" @default.
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• W2498528043 doi "https://doi.org/10.1016/b978-0-12-374420-3.00138-8" @default.
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