Matches in SemOpenAlex for { <https://semopenalex.org/work/W2498702964> ?p ?o ?g. }
- W2498702964 endingPage "191" @default.
- W2498702964 startingPage "175" @default.
- W2498702964 abstract "In response to the need to treat disorders such as Crohn’s disease, rheumatoid arthritis, allergies, and diabetes, the pharmaceutical industry has pursued the development of cytokines as therapeutic agents. Cytokines possess unique characteristics that are distinctly different than small molecule drugs. These hormone-like proteins possess complex structural features, demonstrate unique binding specificities and, in many cases, share overlapping physiological functions. These characteristics make development of cytokine therapeutics a challenge to drug-development scientists. Preclinical development of these molecules is complicated by the challenge of differentiating between toxicity and exaggerated immunopharmacology and understanding and analyzing the impact of antidrug antibody on the pharmacodynamics and pharmacokinetics of the parent compound. Regulatory agencies have recognized these issues and established guidance documents to address the nonclinical development of biological products. Several examples, including the nonclinical development of interleukin (IL)-, IL-5 antagonists, IL-6, IL-10, and IL-18 are reviewed in the context of these issues." @default.
- W2498702964 created "2016-08-23" @default.
- W2498702964 creator A5016943364 @default.
- W2498702964 creator A5045328073 @default.
- W2498702964 date "2007-01-01" @default.
- W2498702964 modified "2023-10-16" @default.
- W2498702964 title "Preclinical Approaches for the Safety Assessment of Cytokines" @default.
- W2498702964 cites W1517678415 @default.
- W2498702964 cites W1532796018 @default.
- W2498702964 cites W155760429 @default.
- W2498702964 cites W1568495307 @default.
- W2498702964 cites W1959153227 @default.
- W2498702964 cites W1964815717 @default.
- W2498702964 cites W1974486772 @default.
- W2498702964 cites W1986609132 @default.
- W2498702964 cites W1996970629 @default.
- W2498702964 cites W1998033848 @default.
- W2498702964 cites W2001634895 @default.
- W2498702964 cites W2003967740 @default.
- W2498702964 cites W2022502525 @default.
- W2498702964 cites W2022535195 @default.
- W2498702964 cites W2024304683 @default.
- W2498702964 cites W2026158588 @default.
- W2498702964 cites W2032460611 @default.
- W2498702964 cites W2041790780 @default.
- W2498702964 cites W2048325240 @default.
- W2498702964 cites W2056225363 @default.
- W2498702964 cites W2058551642 @default.
- W2498702964 cites W2065997245 @default.
- W2498702964 cites W2067388034 @default.
- W2498702964 cites W2072163633 @default.
- W2498702964 cites W2077242971 @default.
- W2498702964 cites W2078701979 @default.
- W2498702964 cites W2087905758 @default.
- W2498702964 cites W2091181842 @default.
- W2498702964 cites W2092445349 @default.
- W2498702964 cites W2098759294 @default.
- W2498702964 cites W2112055772 @default.
- W2498702964 cites W2135392289 @default.
- W2498702964 cites W2149168537 @default.
- W2498702964 cites W2149663244 @default.
- W2498702964 cites W2160272188 @default.
- W2498702964 cites W2161074777 @default.
- W2498702964 cites W2166899308 @default.
- W2498702964 cites W4246456000 @default.
- W2498702964 cites W4247673683 @default.
- W2498702964 cites W72719101 @default.
- W2498702964 cites W2051694648 @default.
- W2498702964 doi "https://doi.org/10.1007/978-1-59745-350-9_9" @default.
- W2498702964 hasPublicationYear "2007" @default.
- W2498702964 type Work @default.
- W2498702964 sameAs 2498702964 @default.
- W2498702964 citedByCount "0" @default.
- W2498702964 crossrefType "book-chapter" @default.
- W2498702964 hasAuthorship W2498702964A5016943364 @default.
- W2498702964 hasAuthorship W2498702964A5045328073 @default.
- W2498702964 hasConcept C151730666 @default.
- W2498702964 hasConcept C203014093 @default.
- W2498702964 hasConcept C2777575956 @default.
- W2498702964 hasConcept C2778690821 @default.
- W2498702964 hasConcept C2779343474 @default.
- W2498702964 hasConcept C2780035454 @default.
- W2498702964 hasConcept C2908738225 @default.
- W2498702964 hasConcept C60644358 @default.
- W2498702964 hasConcept C64903051 @default.
- W2498702964 hasConcept C70721500 @default.
- W2498702964 hasConcept C71924100 @default.
- W2498702964 hasConcept C74187038 @default.
- W2498702964 hasConcept C86803240 @default.
- W2498702964 hasConcept C8891405 @default.
- W2498702964 hasConcept C98274493 @default.
- W2498702964 hasConceptScore W2498702964C151730666 @default.
- W2498702964 hasConceptScore W2498702964C203014093 @default.
- W2498702964 hasConceptScore W2498702964C2777575956 @default.
- W2498702964 hasConceptScore W2498702964C2778690821 @default.
- W2498702964 hasConceptScore W2498702964C2779343474 @default.
- W2498702964 hasConceptScore W2498702964C2780035454 @default.
- W2498702964 hasConceptScore W2498702964C2908738225 @default.
- W2498702964 hasConceptScore W2498702964C60644358 @default.
- W2498702964 hasConceptScore W2498702964C64903051 @default.
- W2498702964 hasConceptScore W2498702964C70721500 @default.
- W2498702964 hasConceptScore W2498702964C71924100 @default.
- W2498702964 hasConceptScore W2498702964C74187038 @default.
- W2498702964 hasConceptScore W2498702964C86803240 @default.
- W2498702964 hasConceptScore W2498702964C8891405 @default.
- W2498702964 hasConceptScore W2498702964C98274493 @default.
- W2498702964 hasLocation W24987029641 @default.
- W2498702964 hasOpenAccess W2498702964 @default.
- W2498702964 hasPrimaryLocation W24987029641 @default.
- W2498702964 hasRelatedWork W1971296504 @default.
- W2498702964 hasRelatedWork W1973829020 @default.
- W2498702964 hasRelatedWork W1979486486 @default.
- W2498702964 hasRelatedWork W2129070589 @default.
- W2498702964 hasRelatedWork W2143400953 @default.
- W2498702964 hasRelatedWork W2152784570 @default.
- W2498702964 hasRelatedWork W2774816252 @default.
- W2498702964 hasRelatedWork W2950198226 @default.
- W2498702964 hasRelatedWork W2991546386 @default.