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• W2498995004 abstract "Impaired postprandial chylomicron metabolism induces hypertriglyceridemia and may increase the risk of atherosclerotic cardiovascular disease. Omega-3 fatty acid ethyl ester (ω-3 FAEE) supplementation decreases plasma triglycerides. However, its effect on postprandial chylomicron metabolism in familial hypercholesterolemia (FH) has not yet been investigated. We aimed to examine the effect of ω-3 FAEE supplementation on postprandial responses in plasma triglycerides, very-low-density lipoprotein (VLDL) apolipoprotein B (apoB)-100, and apoB-48 in FH patients receiving standard cholesterol-lowering treatment. We carried out an 8-week open-label, randomized, crossover intervention trial to test the effect of oral supplementation with 4 g/d ω-3 FAEE (46% eicosapentaenoic acid and 38% docosahexaenoic acid) on postprandial triglyceride, VLDL-apoB-100, and apoB-48 responses in FH patients after ingestion of an oral fat load. Plasma total and incremental triglyceride, VLDL-apoB-100, and apoB-48 0- to 10-hour area under the curve (AUC). ω-3 FAEE supplementation significantly (P < .05 in all) reduced concentrations of fasting plasma triglyceride (−20%), apoB (−8%), VLDL-apoB-100 (−26%), and apoB-48 (−36%); as well as systolic blood pressure (−6%) and diastolic blood pressure (−6%). Postprandial triglyceride and VLDL-apoB-100 total AUCs (−19% and −26%, respectively; P < .01) and incremental AUCs (−18% and −35%, respectively; P < .05), as well as postprandial apoB-48 total AUC (−30%; P < .02) were significantly reduced by ω-3 FAEE supplementation. Supplementation with ω-3 FAEEs improves postprandial lipemia in FH patients receiving standard care; this may have implications for further reducing atherosclerotic cardiovascular disease in this high-risk patient group." @default.
• W2498995004 created "2016-08-23" @default.
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• W2498995004 date "2016-10-01" @default.
• W2498995004 modified "2023-10-16" @default.
• W2498995004 title "ω-3 Fatty Acid Ethyl Esters Diminish Postprandial Lipemia in Familial Hypercholesterolemia" @default.
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• W2498995004 doi "https://doi.org/10.1210/jc.2016-2217" @default.
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