Matches in SemOpenAlex for { <https://semopenalex.org/work/W2499004745> ?p ?o ?g. }
- W2499004745 abstract "Platelets possess three P2 receptors: two (P2Y1 and P2Y12) are receptors for ADP, and one (P2X1) is a receptor for ATP. P2Y1, a Gq-coupled receptor, is responsible for mobilization of Ca2 + from internal stores and mediates ADP-induced platelet shape change and rapidly reversible aggregation. P2Y12, a Gi-coupled receptor, mediates progressive and sustained ADP-induced platelet aggregation not preceded by shape change, and amplifies platelet secretion induced by strong agonists. The combined actions of P2Y1 and P2Y12 are necessary for full platelet aggregation. Both receptors play roles not only in hemostasis and thrombosis, but also in inflammation and atherogenesis. P2Y12 is also involved in tumor growth and metastasis. P2Y12 is defective in patients with a bleeding diathesis, and is an established target for antithrombotic drugs. P2X1 is a widely distributed ligand-gated ion channel. In human platelets, ATP binding to P2X1 induces platelet shape change, and contributes to aggregation and secretion induced by low concentrations of collagen or thromboxane A2, but its most important feature in platelet function is probably its contribution to shear-induced platelet aggregation." @default.
- W2499004745 created "2016-08-23" @default.
- W2499004745 creator A5086743821 @default.
- W2499004745 date "2013-01-01" @default.
- W2499004745 modified "2023-09-28" @default.
- W2499004745 title "The Platelet P2 Receptors" @default.
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