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- W2499011784 abstract "ABSTRACT Calcitonin gene-related peptide (CGRP) and adrenomedullin (AM) are two structurally related peptides. They are synthesized and secreted by many mammalian tissues, including the central nervous system. The two peptides, which were initially described as vasodilators, are now considered as multifunctional regulatory agents. Their cellular actions are mediated by pharmacologically distinct receptors, each comprising two subunits, a classic seven-transmembrane-spanning G-protein-coupled receptor (GPCR) and one of three single-transmembrane-spanning accessory receptor activity-modifying proteins (RAMP). Two GPCRs, namely the calcitonin receptor (CTR) and calcitonin receptor-like receptor (CLR), contribute to CGRP/AM receptor phenotypes. In the brain, CGRP and AM are widely expressed and have been shown to activate, in addition to the vasodilator effect, several autonomic centers involved in the regulation of fluid and electrolyte balance. In addition, they have modulatory effects on the synthesis and release of several other neuropeptides. The potent vasodilator activity of CGRP in cerebral microvasculature is possibly relevant to the pathology of migraine." @default.
- W2499011784 created "2016-08-23" @default.
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- W2499011784 date "2006-01-01" @default.
- W2499011784 modified "2023-09-25" @default.
- W2499011784 title "CGRP and Adrenomedullin in the Brain" @default.
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- W2499011784 doi "https://doi.org/10.1016/b978-012369442-3/50109-4" @default.
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