Matches in SemOpenAlex for { <https://semopenalex.org/work/W2499053504> ?p ?o ?g. }
- W2499053504 endingPage "416" @default.
- W2499053504 startingPage "411" @default.
- W2499053504 abstract "ABSTRACT Leishmaniasis and Chagas disease affect millions of people in tropical and subtropical regions. Drugs used currently to treat such diseases often present undesirable side effects and low efficiency. The aim of this work was to identify extracts and isolated compounds from the genus Lippia with leishmanicidal and trypanocidal activity. Fifteen extracts from different plant parts of Lippia species with partially known chemical compositions, four partition fractions, six compounds and a mixture of four interconverting flavanones previously isolated from Lippia salviaefolia and Lippia lupulina were assayed in vitro towards epimastigote forms of Trypanosoma cruzi and promastigote forms of Leishmania amazonensis. The root extract of L. lupulina had potent activity against T. cruzi and L. amazonensis (IC50 of 20.0 and 54.5 µg mL-1, respectively). The triterpenoid oleanonic acid showed the strongest activity against these protozoans (IC50 of 18.5 and 29.9 µM, respectively). Our results indicate that Lippia plants and their derivatives deserve further investigation in the search for new antiprotozoal drugs, particularly for the treatment of leishmaniasis and Chagas disease." @default.
- W2499053504 created "2016-08-23" @default.
- W2499053504 creator A5012876065 @default.
- W2499053504 creator A5021681470 @default.
- W2499053504 creator A5025118617 @default.
- W2499053504 creator A5031589759 @default.
- W2499053504 creator A5037269214 @default.
- W2499053504 creator A5046533557 @default.
- W2499053504 creator A5078893467 @default.
- W2499053504 creator A5086215591 @default.
- W2499053504 date "2016-12-01" @default.
- W2499053504 modified "2023-09-30" @default.
- W2499053504 title "Oleanonic acid from Lippia lupulina (Verbenaceae) shows strong in vitro antileishmanial and antitrypanosomal activity" @default.
- W2499053504 cites W1536496993 @default.
- W2499053504 cites W1833793080 @default.
- W2499053504 cites W1847214533 @default.
- W2499053504 cites W1967775929 @default.
- W2499053504 cites W1973105583 @default.
- W2499053504 cites W1981366807 @default.
- W2499053504 cites W1986097129 @default.
- W2499053504 cites W1992652969 @default.
- W2499053504 cites W1992716708 @default.
- W2499053504 cites W2002493949 @default.
- W2499053504 cites W2015446287 @default.
- W2499053504 cites W2021494920 @default.
- W2499053504 cites W2030151364 @default.
- W2499053504 cites W2032332145 @default.
- W2499053504 cites W2043959828 @default.
- W2499053504 cites W2045272567 @default.
- W2499053504 cites W2046144222 @default.
- W2499053504 cites W2046849077 @default.
- W2499053504 cites W2047950233 @default.
- W2499053504 cites W2048959206 @default.
- W2499053504 cites W2049464035 @default.
- W2499053504 cites W2058019665 @default.
- W2499053504 cites W2074297610 @default.
- W2499053504 cites W2085765756 @default.
- W2499053504 cites W2086613620 @default.
- W2499053504 cites W2114023043 @default.
- W2499053504 cites W2118000670 @default.
- W2499053504 cites W2124295042 @default.
- W2499053504 cites W2135664039 @default.
- W2499053504 cites W2161670666 @default.
- W2499053504 cites W2167410541 @default.
- W2499053504 doi "https://doi.org/10.1590/1809-4392201600204" @default.
- W2499053504 hasPublicationYear "2016" @default.
- W2499053504 type Work @default.
- W2499053504 sameAs 2499053504 @default.
- W2499053504 citedByCount "12" @default.
- W2499053504 countsByYear W24990535042017 @default.
- W2499053504 countsByYear W24990535042018 @default.
- W2499053504 countsByYear W24990535042020 @default.
- W2499053504 countsByYear W24990535042021 @default.
- W2499053504 countsByYear W24990535042022 @default.
- W2499053504 countsByYear W24990535042023 @default.
- W2499053504 crossrefType "journal-article" @default.
- W2499053504 hasAuthorship W2499053504A5012876065 @default.
- W2499053504 hasAuthorship W2499053504A5021681470 @default.
- W2499053504 hasAuthorship W2499053504A5025118617 @default.
- W2499053504 hasAuthorship W2499053504A5031589759 @default.
- W2499053504 hasAuthorship W2499053504A5037269214 @default.
- W2499053504 hasAuthorship W2499053504A5046533557 @default.
- W2499053504 hasAuthorship W2499053504A5078893467 @default.
- W2499053504 hasAuthorship W2499053504A5086215591 @default.
- W2499053504 hasBestOaLocation W24990535041 @default.
- W2499053504 hasConcept C112418997 @default.
- W2499053504 hasConcept C136764020 @default.
- W2499053504 hasConcept C159047783 @default.
- W2499053504 hasConcept C202751555 @default.
- W2499053504 hasConcept C203014093 @default.
- W2499053504 hasConcept C2776555147 @default.
- W2499053504 hasConcept C2776635100 @default.
- W2499053504 hasConcept C2777278459 @default.
- W2499053504 hasConcept C2777512926 @default.
- W2499053504 hasConcept C2777625466 @default.
- W2499053504 hasConcept C2777752497 @default.
- W2499053504 hasConcept C2777769030 @default.
- W2499053504 hasConcept C2780096663 @default.
- W2499053504 hasConcept C2781092759 @default.
- W2499053504 hasConcept C41008148 @default.
- W2499053504 hasConcept C55493867 @default.
- W2499053504 hasConcept C556039675 @default.
- W2499053504 hasConcept C59822182 @default.
- W2499053504 hasConcept C71924100 @default.
- W2499053504 hasConcept C71928629 @default.
- W2499053504 hasConcept C86803240 @default.
- W2499053504 hasConcept C89423630 @default.
- W2499053504 hasConceptScore W2499053504C112418997 @default.
- W2499053504 hasConceptScore W2499053504C136764020 @default.
- W2499053504 hasConceptScore W2499053504C159047783 @default.
- W2499053504 hasConceptScore W2499053504C202751555 @default.
- W2499053504 hasConceptScore W2499053504C203014093 @default.
- W2499053504 hasConceptScore W2499053504C2776555147 @default.
- W2499053504 hasConceptScore W2499053504C2776635100 @default.
- W2499053504 hasConceptScore W2499053504C2777278459 @default.
- W2499053504 hasConceptScore W2499053504C2777512926 @default.
- W2499053504 hasConceptScore W2499053504C2777625466 @default.
- W2499053504 hasConceptScore W2499053504C2777752497 @default.