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- W2499208093 abstract "Abstract This chapter outlines and discusses the principles and the practical tools of the scientific discipline of stereology with a focus on several established and novel (unpublished) sampling procedures. These sampling strategies are applied to whole three-dimensional organs, well-defined fragments of organs, and ultimately to two-dimensional sections interrogated using a range of stereological probes including points, lines, curves, frames, and optical and physical disectors. The chapter provides the toxicologic pathologist with a versatile toolbox of 9 sampling designs at the organ level and 38 distinct estimators of individual total structural characteristics. The designs and estimators are tailor-made for addressing frequently encountered quantitative problems in toxicologic pathology. For the sampling of tissue at the organ level, sampling designs are described in sufficient detail to allow their implementation. Numerous practical examples are illustrated and a few examples are explained in detail with accompanying computations in the appendices. Statistical error (coefficient of error, CE), the variability associated with the stereological procedure, is provided for most described estimators (with or without the use of the proportionator)." @default.
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- W2499208093 date "2013-01-01" @default.
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- W2499208093 title "Stereological Principles and Sampling Procedures for Toxicologic Pathologists" @default.
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- W2499208093 doi "https://doi.org/10.1016/b978-0-12-415759-0.00008-x" @default.
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