Matches in SemOpenAlex for { <https://semopenalex.org/work/W249927178> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W249927178 abstract "Following the evaluation of radiolabeled MAbs for scintigraphic imaging or therapy, low tumor uptake emerged as one of the most prominent problems. The aim of this investigation was to examine the influence of interferon (IFN)-{alpha}2b in augmenting uptake of Tc-99m labeled antimelanoma MAb 31.3 in nude mice bearing experimental human melanoma. MAb was labeled with Tc-99m by our ascorbic acid mediated reduction technique, analyzed and 20 {mu}g containing 40-120 {mu}Ci Tc-99m were administered i.v., 1 hr following i.m. or i.v. administration of 10K, 20K, or 100K i.u. IFN-{alpha}2b. Animals receiving 0.9% saline similarly served as controls. 4 and 24 hrs later, animals were sacrificed, imaged, and dissected for tissue distribution studies. Tumor blood flow was measured before and after administration of IFN by color Doppler imaging technique, intratumoral temperature was recorded using thermocouples, and tumor histology was performed to visualize tumor lymphocytic infiltration. Although no excessive lymphocytic infiltration was seen within 72 hr post-injection of IFN, and only a modest increase in tumor temperature was noted, a significant increase in blood flow was observed within 45 min. as differentiated by amplitudes at peak systolic and end diastolic cardiac cycles. The best tumor uptake enhancement was noted at 24 hr followingmore » i.m. administration of 20K i.u. IFN and measured greater than 300% of the control value (7.2{plus_minus}1.2%/g vs. 2.2{plus_minus}1.4%/g). IFN-{alpha}2b enhances tumor blood flow in experimental tumors and significantly augments the uptake of radiolabeled MAbs.« less" @default.
- W249927178 created "2016-06-24" @default.
- W249927178 creator A5010394701 @default.
- W249927178 creator A5017725276 @default.
- W249927178 creator A5030295067 @default.
- W249927178 date "1994-05-01" @default.
- W249927178 modified "2023-09-23" @default.
- W249927178 title "Augmenting tumor uptake of Tc-99m monoclonal antibodies (MAbs) with biological response modifiers: Influence of interferon" @default.
- W249927178 hasPublicationYear "1994" @default.
- W249927178 type Work @default.
- W249927178 sameAs 249927178 @default.
- W249927178 citedByCount "0" @default.
- W249927178 crossrefType "journal-article" @default.
- W249927178 hasAuthorship W249927178A5010394701 @default.
- W249927178 hasAuthorship W249927178A5017725276 @default.
- W249927178 hasAuthorship W249927178A5030295067 @default.
- W249927178 hasConcept C126322002 @default.
- W249927178 hasConcept C142724271 @default.
- W249927178 hasConcept C158846371 @default.
- W249927178 hasConcept C159654299 @default.
- W249927178 hasConcept C185592680 @default.
- W249927178 hasConcept C203014093 @default.
- W249927178 hasConcept C2776178377 @default.
- W249927178 hasConcept C2777658100 @default.
- W249927178 hasConcept C2909179924 @default.
- W249927178 hasConcept C2989005 @default.
- W249927178 hasConcept C502942594 @default.
- W249927178 hasConcept C542903549 @default.
- W249927178 hasConcept C71924100 @default.
- W249927178 hasConceptScore W249927178C126322002 @default.
- W249927178 hasConceptScore W249927178C142724271 @default.
- W249927178 hasConceptScore W249927178C158846371 @default.
- W249927178 hasConceptScore W249927178C159654299 @default.
- W249927178 hasConceptScore W249927178C185592680 @default.
- W249927178 hasConceptScore W249927178C203014093 @default.
- W249927178 hasConceptScore W249927178C2776178377 @default.
- W249927178 hasConceptScore W249927178C2777658100 @default.
- W249927178 hasConceptScore W249927178C2909179924 @default.
- W249927178 hasConceptScore W249927178C2989005 @default.
- W249927178 hasConceptScore W249927178C502942594 @default.
- W249927178 hasConceptScore W249927178C542903549 @default.
- W249927178 hasConceptScore W249927178C71924100 @default.
- W249927178 hasLocation W2499271781 @default.
- W249927178 hasOpenAccess W249927178 @default.
- W249927178 hasPrimaryLocation W2499271781 @default.
- W249927178 hasRelatedWork W1526298767 @default.
- W249927178 hasRelatedWork W1551923230 @default.
- W249927178 hasRelatedWork W1603164742 @default.
- W249927178 hasRelatedWork W1650323004 @default.
- W249927178 hasRelatedWork W1753213252 @default.
- W249927178 hasRelatedWork W1842765736 @default.
- W249927178 hasRelatedWork W1990403829 @default.
- W249927178 hasRelatedWork W2019764521 @default.
- W249927178 hasRelatedWork W2071717704 @default.
- W249927178 hasRelatedWork W2089547293 @default.
- W249927178 hasRelatedWork W2105036645 @default.
- W249927178 hasRelatedWork W2110711861 @default.
- W249927178 hasRelatedWork W2125552487 @default.
- W249927178 hasRelatedWork W2170390829 @default.
- W249927178 hasRelatedWork W2305605425 @default.
- W249927178 hasRelatedWork W2338663983 @default.
- W249927178 hasRelatedWork W2370503441 @default.
- W249927178 hasRelatedWork W2406917397 @default.
- W249927178 hasRelatedWork W2475291722 @default.
- W249927178 hasRelatedWork W3028876992 @default.
- W249927178 hasVolume "35" @default.
- W249927178 isParatext "false" @default.
- W249927178 isRetracted "false" @default.
- W249927178 magId "249927178" @default.
- W249927178 workType "article" @default.