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- W2499286871 abstract "Aim. To assess renal artery stenting (RAS) effectiveness and safety in patients with renovascular hypertension (RVH) duration over 10 years. Material and methods. Seventy-eight patients were randomized into main (n=26) and placebo groups (n=52). Primary end-point was systolic blood pressure (SBP) level. Secondary end-points included: restenosis incidence; glomerular filtration rate (GFR); effective renal plasma flow (ERPF); creatinine level and microalbuminuria (MAU); quality of life (QoL); renal biopsy and immuno-hystochemical assay data; renal vessel calcification; cerebral metabolism level. Results. RAS resulted in average BP decrease from 181/107 to 142/93 mm Hg; after 6 weeks, no patient achieved target BP levels. Restenosis at 12 months was observed in 17% of the patients from both groups; another RAS was needed in 8%. According to dynamic nephroscintigraphy results, GFR reduced by 5% (p <0,05), and ERPF - by 3% (p <0,05). Creatinine level decreased by 3% (p <0,01), and MAU - by 7% (p <0,05). Assessed by SF-36 questionnaire, QoL was normal in 14-29% only. Conclusion. RAS remains an ineffective method of RVH treatment, even though it prevents renal artery thrombosis and improves RVH control to some extent." @default.
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- W2499286871 date "2008-01-01" @default.
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- W2499286871 title "Stenting and cell technologies in the treatment of atherosclerotic renovascular hypertension" @default.
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