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- W2499334145 abstract "This chapter focuses on information obtained by molecular genetic analysis in the diagnosis, treatment, and overall understanding of pediatric cardiovascular disease (CVD) pathogenesis by examining the more prevalent congenital heart defects (CHD), dysrhythmias, and cardiomyopathies, as well as sporadic and acquired disorders. These defects are common causes of mortality and morbidity in infants and children, particularly, during the perinatal period. Cardiovascular abnormalities represent the most common class of birth defect, affecting approximately 1 in every 120 infants each year. The high incidence of cardiovascular defects in infants and children represents an enormous burden and cost borne by the families, health-care providers, and society at large. Recent advances in molecular genetics have shown that specific genetic and molecular factors are linked to CHD, allowing their identification on the human chromosome and providing a great opportunity for improving genetic diagnostics and future gene therapy. Acquired diseases in neonates and children include Kawasaki disease, acute and chronic rheumatic cardiac disease, infective endocarditis, and myocarditis. Molecular genetic technology has been applied in a limited fashion in the analysis of these diseases and could improve the clinical diagnosis. The chapter presents a survey of the pediatric cardiologist's armamentarium with regard to molecular and genetic analysis. It highlights the current use of molecular diagnostic methods, including microarray, gene mapping, proteomic, transgenic, and stem cell technologies, as well as future directions in both clinical application and research." @default.
- W2499334145 created "2016-08-23" @default.
- W2499334145 creator A5002135839 @default.
- W2499334145 creator A5022739391 @default.
- W2499334145 creator A5079465394 @default.
- W2499334145 date "2007-01-01" @default.
- W2499334145 modified "2023-09-23" @default.
- W2499334145 title "Congenital and Acquired Heart Disease" @default.
- W2499334145 cites W1033793070 @default.
- W2499334145 cites W1240163258 @default.
- W2499334145 cites W1481913624 @default.
- W2499334145 cites W1484379620 @default.
- W2499334145 cites W1487741670 @default.
- W2499334145 cites W1488372279 @default.
- W2499334145 cites W1491803208 @default.
- W2499334145 cites W1495427089 @default.
- W2499334145 cites W1495506271 @default.
- W2499334145 cites W1497644393 @default.
- W2499334145 cites W1506134312 @default.
- W2499334145 cites W1506409704 @default.
- W2499334145 cites W1509578353 @default.
- W2499334145 cites W1512160235 @default.
- W2499334145 cites W1514770795 @default.
- W2499334145 cites W1522393141 @default.
- W2499334145 cites W1533387942 @default.
- W2499334145 cites W1545064199 @default.
- W2499334145 cites W1546523805 @default.
- W2499334145 cites W1557009310 @default.
- W2499334145 cites W1569055531 @default.
- W2499334145 cites W1590222977 @default.
- W2499334145 cites W1590960934 @default.
- W2499334145 cites W1601031354 @default.
- W2499334145 cites W1602684793 @default.
- W2499334145 cites W1607363557 @default.
- W2499334145 cites W1693754698 @default.
- W2499334145 cites W1709299970 @default.
- W2499334145 cites W1732609050 @default.
- W2499334145 cites W1833362241 @default.
- W2499334145 cites W1870897498 @default.
- W2499334145 cites W1906119900 @default.
- W2499334145 cites W1927233045 @default.
- W2499334145 cites W1939326986 @default.
- W2499334145 cites W1951867641 @default.
- W2499334145 cites W1964071888 @default.
- W2499334145 cites W1965869341 @default.
- W2499334145 cites W1967125902 @default.
- W2499334145 cites W1969174703 @default.
- W2499334145 cites W1970781523 @default.
- W2499334145 cites W1971738870 @default.
- W2499334145 cites W1972925152 @default.
- W2499334145 cites W1973431915 @default.
- W2499334145 cites W1974522463 @default.
- W2499334145 cites W1975494067 @default.
- W2499334145 cites W1976535783 @default.
- W2499334145 cites W1977003877 @default.
- W2499334145 cites W1977541541 @default.
- W2499334145 cites W1977758513 @default.
- W2499334145 cites W1978221717 @default.
- W2499334145 cites W1978747411 @default.
- W2499334145 cites W1978902758 @default.
- W2499334145 cites W1979854824 @default.
- W2499334145 cites W1980989050 @default.
- W2499334145 cites W1983315678 @default.
- W2499334145 cites W1984500062 @default.
- W2499334145 cites W1984506440 @default.
- W2499334145 cites W1985411380 @default.
- W2499334145 cites W1986155425 @default.
- W2499334145 cites W1986607576 @default.
- W2499334145 cites W1986947590 @default.
- W2499334145 cites W1988173672 @default.
- W2499334145 cites W1989014460 @default.
- W2499334145 cites W1989321253 @default.
- W2499334145 cites W1989457690 @default.
- W2499334145 cites W1991465058 @default.
- W2499334145 cites W1991671544 @default.
- W2499334145 cites W1991690216 @default.
- W2499334145 cites W1991888662 @default.
- W2499334145 cites W1992752077 @default.
- W2499334145 cites W1994416947 @default.
- W2499334145 cites W1994474466 @default.
- W2499334145 cites W1994761680 @default.
- W2499334145 cites W1995683620 @default.
- W2499334145 cites W1995697852 @default.
- W2499334145 cites W1997267758 @default.
- W2499334145 cites W1999241105 @default.
- W2499334145 cites W1999275474 @default.
- W2499334145 cites W2000657430 @default.
- W2499334145 cites W2001260034 @default.
- W2499334145 cites W2001632160 @default.
- W2499334145 cites W2002451854 @default.
- W2499334145 cites W2004537703 @default.
- W2499334145 cites W2005055166 @default.
- W2499334145 cites W2006887142 @default.
- W2499334145 cites W2007122274 @default.
- W2499334145 cites W2007160780 @default.
- W2499334145 cites W2008023960 @default.
- W2499334145 cites W2008416986 @default.
- W2499334145 cites W2009041906 @default.
- W2499334145 cites W2010186048 @default.
- W2499334145 cites W2010844744 @default.